Marchf2 MGI Mouse Gene Detail - MGI:1925915 - membrane associated ring-CH-type finger 2

Symbol

Marchf2
Name

membrane associated ring-CH-type finger 2
Synonyms

9530046H09Rik, March2, MGC:7259

Feature Type

protein coding gene
IDs

MGI:1925915
NCBI Gene: 224703
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:33904666-33937644 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 17.98 cM
Mapping Data

2 experiments

SNPs within 2kb

4 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925915	protein coding gene	Chr17:33904666-33937651 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023534	protein coding gene	Chr17:33603191-33648859 (-)
A/J	MGP_AJ_G0023493	protein coding gene	Chr17:32448264-32493179 (-)
AKR/J	MGP_AKRJ_G0023459	protein coding gene	Chr17:32832331-32867626 (-)
BALB/cJ	MGP_BALBcJ_G0023497	protein coding gene	Chr17:32600894-32633934 (-)
C3H/HeJ	MGP_C3HHeJ_G0023260	protein coding gene	Chr17:33177139-33210094 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023941	protein coding gene	Chr17:34843637-34881726 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021414	protein coding gene	Chr17:29976994-30006378 (-)
CAST/EiJ	MGP_CASTEiJ_G0022762	protein coding gene	Chr17:33289526-33331422 (-)
CBA/J	MGP_CBAJ_G0023236	protein coding gene	Chr17:36247462-36285854 (-)
DBA/2J	MGP_DBA2J_G0023365	protein coding gene	Chr17:31841235-31874460 (-)
FVB/NJ	MGP_FVBNJ_G0023334	protein coding gene	Chr17:31694093-31730423 (-)
LP/J	MGP_LPJ_G0023443	protein coding gene	Chr17:33890152-33924411 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023354	protein coding gene	Chr17:35304910-35343340 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023981	protein coding gene	Chr17:33154412-33189886 (-)
PWK/PhJ	MGP_PWKPhJ_G0022510	protein coding gene	Chr17:30733301-30767115 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022326	protein coding gene	Chr17:31136451-31169307 (-)
WSB/EiJ	MGP_WSBEiJ_G0022821	protein coding gene	Chr17:33200021-33236581 (-)

Human Ortholog

MARCHF2, membrane associated ring-CH-type finger 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MARCHF2, membrane associated ring-CH-type finger 2
Synonyms

HSPC240, MARCH2, MARCH-II, RNF172
Links

HGNC:28038

NCBI Gene ID: 51257

neXtProt AC: NX_Q9P0N8

UniProt: Q9P0N8
Chr Location

19p13.2; chr19:8413270-8439017 (+) GRCh38

MGI Vertebrate Homology

Marchf2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MARCHF2
Gene Tree

Marchf2

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Phenotype Summary

13 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

4
Gene trapped

3
Targeted

2
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit resistance to bacterial and viral infection with reduced bacterial or viral load and increased cytokine production in addition to increased lethality induced by LPS treatment.

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All GO Annotations

28
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

869
Tissues

32
cDNA Data

14
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase marchf2

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All Sequences

75
RefSeq

6
UniProt

9
CCDS

CCDS28627.1, CCDS57064.1

Ensembl

ENSMUSG00000079557 (Evidence)
NCBI Gene

224703

			Length	Strain/Species	Flank
genomic	ENSMUSG00000079557	Ensembl Gene Model \| MGI Sequence Detail	32979	C57BL/6J	± kb
transcript	ENSMUST00000066121	Ensembl \| MGI Sequence Detail	3400	Not Applicable
polypeptide	ENSMUSP00000065225	Ensembl \| MGI Sequence Detail	287	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000010176 E3 ubiquitin-protein ligase MARCHF2

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR011016 Zinc finger, RING-CH-type

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

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All nucleic 15

cDNA 14

Primer pair 1

Microarray probesets 3

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MGI:6368850

Summaries

All 38

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Marchf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr147452	Chr17:33937669-33937686 (-)	-34 bp
Tssr147451	Chr17:33937611-33937664 (-)	6 bp
Tssr147450	Chr17:33932346-33932364 (-)	5,289 bp
Tssr147449	Chr17:33932327-33932338 (-)	5,311 bp
Tssr147448	Chr17:33921271-33921276 (-)	16,370 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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