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Fbxo22 Gene Detail
Summary
  • Symbol
    Fbxo22
  • Name
    F-box protein 22
  • Synonyms
    0610033L19Rik, 1600016C16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926014
    NCBI Gene: 71999
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:55116219-55131717 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 29.86 cM, cytoband C
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    458 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926014
 protein coding gene Chr9:55116209-55131717 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034839
 protein coding gene Chr9:54292269-54311074 (+)
A/J MGP_AJ_G0034820
 protein coding gene Chr9:52547799-52564351 (+)
AKR/J MGP_AKRJ_G0034749
 protein coding gene Chr9:53750388-53768553 (+)
BALB/cJ MGP_BALBcJ_G0034812
 protein coding gene Chr9:52320799-52338024 (+)
C3H/HeJ MGP_C3HHeJ_G0034522
 protein coding gene Chr9:54212762-54228224 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035331
 protein coding gene Chr9:55804898-55821591 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032243
 protein coding gene Chr9:51953555-51969882 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0034493
 protein coding gene Chr9:57752840-57771814 (+)
DBA/2J MGP_DBA2J_G0034652
 protein coding gene Chr9:52440623-52456231 (+)
FVB/NJ MGP_FVBNJ_G0034594
 protein coding gene Chr9:51641715-51657227 (+)
LP/J MGP_LPJ_G0034735
 protein coding gene Chr9:54602158-54619755 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034637
 protein coding gene Chr9:59264064-59281661 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035353
 protein coding gene Chr9:53767111-53784643 (+)
PWK/PhJ MGP_PWKPhJ_G0033548
 protein coding gene Chr9:52425675-52442200 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033383
 protein coding gene Chr9:54025904-54042265 (+)
WSB/EiJ MGP_WSBEiJ_G0033956
 protein coding gene Chr9:53722682-53740692 (+)



Homology
more
  • Human Ortholog
    FBXO22, F-box protein 22
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBXO22, F-box protein 22
  • Synonyms
    FBX22, FISTC1
  • Links
    NCBI Gene ID: 26263
    neXtProt AC: NX_Q8NEZ5
    UniProt: Q8NEZ5

  • Chr Location
    15q24.2; chr15:75903876-75942511 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele display infertility, decreased grip strength and decreased prepulse inhibition. Mice homozygous for a second null allele display partial lethality and decreased cell proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71999 NCBI Gene Model | MGI Sequence Detail 15499 C57BL/6J ±  kb
    transcript NM_028049 RefSeq | MGI Sequence Detail 2117 C57BL/6  
    polypeptide Q78JE5 UniProt | EBI | MGI Sequence Detail 402 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1919249
    References
    more
    • Summaries
      All 29
      Gene Ontology 3
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory