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Usp54 Gene Detail
Summary
  • Symbol
    Usp54
  • Name
    ubiquitin specific peptidase 54
  • Synonyms
    4930429G18Rik, C030002J06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926037
    NCBI Gene: 78787
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:20598980-20691131 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 11.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1702 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926037
 protein coding gene Chr14:20598980-20694559 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021039
 protein coding gene Chr14:13315192-13384146 (-)
A/J MGP_AJ_G0020988
 protein coding gene Chr14:13002191-13073662 (-)
AKR/J MGP_AKRJ_G0020965
 protein coding gene Chr14:13527527-13598162 (-)
BALB/cJ MGP_BALBcJ_G0020991
 protein coding gene Chr14:13106276-13176390 (-)
C3H/HeJ MGP_C3HHeJ_G0020775
 protein coding gene Chr14:13465275-13538625 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021424
 protein coding gene Chr14:13811094-13882073 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018992
 protein coding gene Chr14:13316266-13385491 (-)
CAST/EiJ MGP_CASTEiJ_G0020299
 protein coding gene Chr14:13226906-13300024 (-)
CBA/J MGP_CBAJ_G0020741
 protein coding gene Chr14:14513076-14590197 (-)
DBA/2J MGP_DBA2J_G0020864
 protein coding gene Chr14:12827971-12897502 (-)
FVB/NJ MGP_FVBNJ_G0020847
 protein coding gene Chr14:12721993-12791328 (-)
LP/J MGP_LPJ_G0020940
 protein coding gene Chr14:13536648-13609697 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020873
 protein coding gene Chr14:14287124-14359164 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021457
 protein coding gene Chr14:13316052-13390510 (-)
PWK/PhJ MGP_PWKPhJ_G0020048
 protein coding gene Chr14:12394900-12467427 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019870
 protein coding gene Chr14:13097094-13173533 (-)
WSB/EiJ MGP_WSBEiJ_G0020355
 protein coding gene Chr14:13301792-13371390 (-)



Homology
more
  • Human Ortholog
    USP54, ubiquitin specific peptidase 54
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP54, ubiquitin specific peptidase 54
  • Synonyms
    bA137L10.3, bA137L10.4, C10orf29
  • Links
    NCBI Gene ID: 159195
    neXtProt AC: NX_Q70EL1
    UniProt: Q70EL1

  • Chr Location
    10q22.2; chr10:73497538-73626117 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    73
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034235 Ensembl Gene Model | MGI Sequence Detail 92152 C57BL/6J ±  kb
    transcript ENSMUST00000022356 Ensembl | MGI Sequence Detail 6580 Not Applicable  
    polypeptide ENSMUSP00000022356 Ensembl | MGI Sequence Detail 1588 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000017193 inactive ubiquitin carboxyl-terminal hydrolase 54
      (term hierarchy)
    • EC
      3.4.19.12
    • InterPro Domains
      IPR052398 Inactive ubiquitin carboxyl-terminal hydrolase
      IPR038765 Papain-like cysteine peptidase superfamily
      IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
      IPR028889 Ubiquitin specific protease domain
    • GlyGen
      Q8BL06 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 73
      cDNA 73

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2145598, MGI:2442602
    References
    more
    • Summaries
      All 37
      Gene Ontology 4
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory