Fbxo43 MGI Mouse Gene Detail - MGI:1926053

Symbol

Fbxo43
Name

F-box protein 43
Synonyms

4930533G20Rik, early mitotic inhibitor 2, Emi2, endogenous meiotic inhibitor 2, XErp1 homolog

Feature Type

protein coding gene
IDs

MGI:1926053
NCBI Gene: 78803
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:36150206-36165030 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 14.46 cM
Mapping Data

1 experiment

SNPs within 2kb

445 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926053	protein coding gene	Chr15:36150206-36170086 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021790	protein coding gene	Chr15:34529687-34544583 (-)
A/J	MGP_AJ_G0021751	protein coding gene	Chr15:33231892-33246717 (-)
AKR/J	MGP_AKRJ_G0021729	protein coding gene	Chr15:34151466-34166435 (-)
BALB/cJ	MGP_BALBcJ_G0021757	protein coding gene	Chr15:33237670-33252479 (-)
C3H/HeJ	MGP_C3HHeJ_G0021532	protein coding gene	Chr15:34121276-34136082 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022196	protein coding gene	Chr15:35835299-35850164 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019734	protein coding gene	Chr15:31044950-31059092 (-)
CAST/EiJ	MGP_CASTEiJ_G0021048	protein coding gene	Chr15:34524132-34538698 (-)
CBA/J	MGP_CBAJ_G0021501	protein coding gene	Chr15:36994400-37009215 (-)
DBA/2J	MGP_DBA2J_G0021625	protein coding gene	Chr15:33054412-33069210 (-)
FVB/NJ	MGP_FVBNJ_G0021603	protein coding gene	Chr15:32453923-32468715 (-)
LP/J	MGP_LPJ_G0021694	protein coding gene	Chr15:34431810-34446686 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021628	protein coding gene	Chr15:40107262-40125414 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022219	protein coding gene	Chr15:34306245-34321065 (-)
PWK/PhJ	MGP_PWKPhJ_G0020792	protein coding gene	Chr15:33071915-33087111 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020630	protein coding gene	Chr15:34004349-34019073 (-)
WSB/EiJ	MGP_WSBEiJ_G0021104	protein coding gene	Chr15:34273916-34288695 (-)

Human Ortholog

FBXO43, F-box protein 43

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FBXO43, F-box protein 43
Synonyms

EMI2, ERP1, FBX43, OOMD12, OZEMA12, SPGF64
Links

HGNC:28521

NCBI Gene ID: 286151

neXtProt AC: NX_Q4G163

UniProt: Q4G163
Chr Location

8q22.2; chr8:100133351-100150569 (-) GRCh38

MGI Vertebrate Homology

Fbxo43 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FBXO43
Gene Tree

Fbxo43

Diseases

1 with human FBXO43 associations

				Human Disease	Mouse Models
				spermatogenic failure 64 IDs spermatogenic failure 64 DOID:0112353 OMIM:619696

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotypes from 2 alleles in 3 genetic backgrounds
4 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

4
Targeted

3
Genomic Mutations

2 involving Fbxo43
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit female and male infertility with arrested meiosis.

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All GO Annotations

18
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

738
Tissues

18
cDNA Data

14
Literature Summary

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fbxo43

ZFIN fbxo43

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All Sequences

47
RefSeq

12
UniProt

3
CCDS

CCDS37060.1

Ensembl

ENSMUSG00000048230 (Evidence)
NCBI Gene

78803

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048230	Ensembl Gene Model \| MGI Sequence Detail	14825	C57BL/6J	± kb
transcript	ENSMUST00000058643	Ensembl \| MGI Sequence Detail	4035	Not Applicable
polypeptide	ENSMUSP00000054125	Ensembl \| MGI Sequence Detail	641	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007412 F-box only protein 43

(term hierarchy)
PDB

2RT9, 5DMS, 5DMV
InterPro Domains

IPR047147 F-box only protein 5/43

IPR002867 IBR domain

IPR044064 Zinc finger ZBR-type domain

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All nucleic 15

cDNA 14

Primer pair 1

Microarray probesets 3

Summaries

All 44

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 12
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345099 Wang X, et al., Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development. BMC Genomics. 2024 Feb 3;25(1):139

TSS for Fbxo43:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr134009	Chr15:36165018-36165023 (-)	9 bp
Tssr134008	Chr15:36165002-36165012 (-)	23 bp
Tssr134007	Chr15:36164986-36164997 (-)	38 bp
Tssr134006	Chr15:36164516-36164518 (-)	513 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24