Stxbp5 MGI Mouse Gene Detail - MGI:1926058 - syntaxin binding protein 5 (tomosyn)

Symbol

Stxbp5
Name

syntaxin binding protein 5 (tomosyn)
Synonyms

0710001E20Rik, 4930565N16Rik, LGL3, mKIAA1006, tomosyn 1

Feature Type

protein coding gene
IDs

MGI:1926058
NCBI Gene: 78808
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:9631291-9776823 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 3.21 cM, cytoband A2
Mapping Data

3 experiments

SNPs within 2kb

4164 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926058	protein coding gene	Chr10:9631285-9776987 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017007	protein coding gene	Chr10:7096935-7245812 (-)
A/J	MGP_AJ_G0016985	protein coding gene	Chr10:6763910-6909010 (-)
AKR/J	MGP_AKRJ_G0016949	protein coding gene	Chr10:6909129-7050579 (-)
BALB/cJ	MGP_BALBcJ_G0016943	protein coding gene	Chr10:6718814-6861895 (-)
C3H/HeJ	MGP_C3HHeJ_G0016768	protein coding gene	Chr10:7070013-7219574 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017405	protein coding gene	Chr10:7241395-7405394 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015110	protein coding gene	Chr10:6244506-6392559 (-)
CAST/EiJ	MGP_CASTEiJ_G0016350	protein coding gene	Chr10:6967131-7117817 (-)
CBA/J	MGP_CBAJ_G0016740	protein coding gene	Chr10:7515539-7681988 (-)
DBA/2J	MGP_DBA2J_G0016848	protein coding gene	Chr10:6661159-6805251 (-)
FVB/NJ	MGP_FVBNJ_G0016843	protein coding gene	Chr10:6612183-6753583 (-)
LP/J	MGP_LPJ_G0016923	protein coding gene	Chr10:6882456-7037796 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016873	protein coding gene	Chr10:7381220-7556638 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017443	protein coding gene	Chr10:6848093-6996344 (-)
PWK/PhJ	MGP_PWKPhJ_G0016135	protein coding gene	Chr10:6625231-6770178 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015918	protein coding gene	Chr10:6944728-7092532 (-)
WSB/EiJ	MGP_WSBEiJ_G0016412	protein coding gene	Chr10:6860806-7014578 (-)

Human Ortholog

STXBP5, syntaxin binding protein 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STXBP5, syntaxin binding protein 5
Synonyms

LGL3, LLGL3, Nbla04300
Links

HGNC:19665

NCBI Gene ID: 134957

neXtProt AC: NX_Q5T5C0

UniProt: Q5T5C0
Chr Location

6q24.3; chr6:147204180-147391010 (+) GRCh38

MGI Vertebrate Homology

Stxbp5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: STXBP5
Gene Tree

Stxbp5

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Phenotype Summary

11 phenotypes from 2 alleles in 4 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

4
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

66 strains or lines available

Mice homozygous for a null allele exhibit some background sensitive prenatal lethality and increased synaptic transmission.

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All GO Annotations

43
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

66
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase stxbp5

ZFIN stxbp5a

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All Sequences

87
RefSeq

26
UniProt

4
CCDS

CCDS35837.2

Ensembl

ENSMUSG00000019790 (Evidence)
NCBI Gene

78808

			Length	Strain/Species	Flank
genomic	ENSMUSG00000019790	Ensembl Gene Model \| MGI Sequence Detail	145533	C57BL/6J	± kb
transcript	ENSMUST00000038213	Ensembl \| MGI Sequence Detail	8825	Not Applicable
polypeptide	ENSMUSP00000044535	Ensembl \| MGI Sequence Detail	1152	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015804 syntaxin-binding protein 5

(term hierarchy)
InterPro Domains

IPR000664 Lethal(2) giant larvae protein

IPR013577 Lethal giant larvae homologue 2

IPR013905 Lethal giant larvae (Lgl)-like, C-terminal domain

IPR042855 v-SNARE, coiled-coil homology domain

IPR001680 WD40 repeat

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

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All nucleic 66

cDNA 66

Microarray probesets 7

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MGI:1921351, MGI:2143879

Summaries

All 49

Developmental Gene Expression 2

Gene Ontology 12

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Stxbp5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96679	Chr10:9776904-9776994 (-)	-126 bp
Tssr96678	Chr10:9774067-9774072 (-)	2,753 bp
Tssr96677	Chr10:9762451-9762469 (-)	14,363 bp
Tssr96676	Chr10:9687736-9687778 (-)	89,066 bp
Tssr96675	Chr10:9658572-9658575 (-)	118,249 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24