Prima1 MGI Mouse Gene Detail - MGI:1926097 - proline rich membrane anchor 1

Symbol

Prima1
Name

proline rich membrane anchor 1
Synonyms

B230212M13Rik

Feature Type

protein coding gene
IDs

MGI:1926097
NCBI Gene: 170952
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr12:103163167-103208409 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 52.90 cM, cytoband F1
Mapping Data

3 experiments

SNPs within 2kb

1490 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926097	protein coding gene	Chr12:103160712-103208967 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020044	protein coding gene	Chr12:104873159-104918394 (-)
A/J	MGP_AJ_G0020000	protein coding gene	Chr12:100836284-100881519 (-)
AKR/J	MGP_AKRJ_G0019976	protein coding gene	Chr12:103678851-103724090 (-)
BALB/cJ	MGP_BALBcJ_G0019986	protein coding gene	Chr12:101191915-101237139 (-)
C3H/HeJ	MGP_C3HHeJ_G0019788	protein coding gene	Chr12:104170706-104215937 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020435	protein coding gene	Chr12:108126369-108171613 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018048	protein coding gene	Chr12:97876380-97923074 (-)
CAST/EiJ	MGP_CASTEiJ_G0019334	protein coding gene	Chr12:99024998-99070351 (-)
CBA/J	MGP_CBAJ_G0019760	protein coding gene	Chr12:112146576-112191862 (-)
DBA/2J	MGP_DBA2J_G0019871	protein coding gene	Chr12:100356998-100402234 (-)
FVB/NJ	MGP_FVBNJ_G0019860	protein coding gene	Chr12:99090364-99138514 (-)
LP/J	MGP_LPJ_G0019947	protein coding gene	Chr12:104713824-104763121 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019900	protein coding gene	Chr12:115599017-115646940 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020464	protein coding gene	Chr12:103217039-103263757 (-)
PWK/PhJ	MGP_PWKPhJ_G0019097	protein coding gene	Chr12:94918588-94964054 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018893	protein coding gene	Chr12:97416530-97463964 (-)
WSB/EiJ	MGP_WSBEiJ_G0019388	protein coding gene	Chr12:104103837-104152183 (-)

Human Ortholog

PRIMA1, proline rich membrane anchor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRIMA1, proline rich membrane anchor 1
Synonyms

PRIMA
Links

HGNC:18319

NCBI Gene ID: 145270

neXtProt AC: NX_Q86XR5

UniProt: Q86XR5
Chr Location

14q32.12; chr14:93718298-93788994 (-) GRCh38

MGI Vertebrate Homology

Prima1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PRIMA1
Gene Tree

Prima1

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Phenotype Summary

2 phenotypes from 1 allele in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

5
Genomic Mutations

1 involving Prima1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

13 strains or lines available

Mice homozygous for a knock-out allele exhibit increased sensitivity to organophosphorus AChE inhibitors.

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All GO Annotations

9
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prima1

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All Sequences

54
RefSeq

8
UniProt

7
CCDS

CCDS26127.1

Ensembl

ENSMUSG00000041669 (Evidence)
NCBI Gene

170952

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041669	Ensembl Gene Model \| MGI Sequence Detail	45243	C57BL/6J	± kb
transcript	ENSMUST00000074416	Ensembl \| MGI Sequence Detail	909	Not Applicable
polypeptide	ENSMUSP00000074017	Ensembl \| MGI Sequence Detail	153	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000013217 proline-rich membrane anchor 1

(term hierarchy)
GlyGen

Q810F0 1 site

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All nucleic 5

cDNA 5

Microarray probesets 2

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MGI:2145067

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 13
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:244526 Mohr F, et al., Dysfunctional Presynaptic M2 Receptors in the Presence of Chronically High Acetylcholine Levels: Data from the PRiMA Knockout Mouse. PLoS One. 2015;10(10):e0141136

TSS for Prima1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr117453	Chr12:103208402-103208407 (-)	4 bp
Tssr117452	Chr12:103202275-103202300 (-)	6,121 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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