Wsb1 MGI Mouse Gene Detail - MGI:1926139 - WD repeat and SOCS box-containing 1

Symbol

Wsb1
Name

WD repeat and SOCS box-containing 1
Synonyms

1110056B13Rik, 2700038M07Rik

Feature Type

protein coding gene
IDs

MGI:1926139
NCBI Gene: 78889
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr11:79130198-79145497 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 46.74 cM, cytoband B5
Mapping Data

2 experiments

SNPs within 2kb

347 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926139	protein coding gene	Chr11:79130198-79145521 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018794	protein coding gene	Chr11:80317385-80333627 (-)
A/J	MGP_AJ_G0018761	protein coding gene	Chr11:77233673-77250712 (-)
AKR/J	MGP_AKRJ_G0018731	protein coding gene	Chr11:79560717-79575819 (-)
BALB/cJ	MGP_BALBcJ_G0018734	protein coding gene	Chr11:77646108-77661200 (-)
C3H/HeJ	MGP_C3HHeJ_G0018548	protein coding gene	Chr11:79597658-79613910 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019186	protein coding gene	Chr11:82791096-82807511 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016821	protein coding gene	Chr11:74182409-74197417 (-)
CAST/EiJ	MGP_CASTEiJ_G0018103	protein coding gene	Chr11:80071810-80093568 (-)
CBA/J	MGP_CBAJ_G0018519	protein coding gene	Chr11:86396035-86416863 (-)
DBA/2J	MGP_DBA2J_G0018627	protein coding gene	Chr11:76789913-76805216 (-)
FVB/NJ	MGP_FVBNJ_G0018616	protein coding gene	Chr11:76390645-76406682 (-)
LP/J	MGP_LPJ_G0018697	protein coding gene	Chr11:80824897-80841303 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018643	protein coding gene	Chr11:86736235-86751138 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019226	protein coding gene	Chr11:79815871-79831174 (-)
PWK/PhJ	MGP_PWKPhJ_G0017873	protein coding gene	Chr11:77602431-77617731 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017664	protein coding gene	Chr11:79422334-79437372 (-)
WSB/EiJ	MGP_WSBEiJ_G0018155	protein coding gene	Chr11:79634205-79649156 (-)

Human Ortholog

WSB1, WD repeat and SOCS box containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WSB1, WD repeat and SOCS box containing 1
Synonyms

SWIP1, WSB-1
Links

HGNC:19221

NCBI Gene ID: 26118

neXtProt AC: NX_Q9Y6I7

UniProt: Q9Y6I7
Chr Location

17q11.1; chr17:27294076-27315926 (+) GRCh38

MGI Vertebrate Homology

Wsb1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WSB1
Gene Tree

Wsb1

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

4
Targeted

5
Genomic Mutations

2 involving Wsb1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

25 strains or lines available

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All GO Annotations

8
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

781
Tissues

13
cDNA Data

22
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA WSB1

Xenbase wsb1

ZFIN wsb1

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All Sequences

72
RefSeq

6
UniProt

10
CCDS

CCDS25118.1

Ensembl

ENSMUSG00000017677 (Evidence)
NCBI Gene

78889

			Length	Strain/Species	Flank
genomic	ENSMUSG00000017677	Ensembl Gene Model \| MGI Sequence Detail	15300	C57BL/6J	± kb
transcript	ENSMUST00000017821	Ensembl \| MGI Sequence Detail	2476	Not Applicable
polypeptide	ENSMUSP00000017821	Ensembl \| MGI Sequence Detail	421	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000017457 WD repeat and SOCS box-containing protein 1

(term hierarchy)
InterPro Domains

IPR020472 G-protein beta WD-40 repeat

IPR001496 SOCS box domain

IPR036036 SOCS box-like domain superfamily

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

IPR051983 WD repeat and SOCS box domain-containing protein

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All nucleic 24

cDNA 22

Primer pair 1

Other 1

Microarray probesets 4

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MGI:1923579

Summaries

All 46

Developmental Gene Expression 6

Gene Ontology 3

Phenotypes 18
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:358004 Chong L, et al., WSB1, a Hypoxia-Inducible E3 Ligase, Promotes Myofibroblast Accumulation and Attenuates Alveolar Epithelial Regeneration in Mouse Lung Fibrosis. Am J Pathol. 2024 May;194(5):656-672

TSS for Wsb1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr109474	Chr11:79145489-79145511 (-)	-3 bp
Tssr109473	Chr11:79141798-79141818 (-)	3,689 bp
Tssr3595	Chr11:79135279-79135293 (-)	10,211 bp
Tssr109472	Chr11:79134282-79134294 (-)	11,209 bp
Tssr109471	Chr11:79134207-79134256 (-)	11,265 bp
Tssr109470	Chr11:79134140-79134171 (-)	11,341 bp
Tssr109469	Chr11:79133317-79133327 (-)	12,175 bp
Tssr109468	Chr11:79130723-79130740 (-)	14,765 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24