Crispld2 MGI Mouse Gene Detail - MGI:1926142 - cysteine-rich secretory protein LCCL domain containing 2

Symbol

Crispld2
Name

cysteine-rich secretory protein LCCL domain containing 2
Synonyms

1810049K24Rik, coffeecrisp, Lgl1

Feature Type

protein coding gene
IDs

MGI:1926142
NCBI Gene: 78892
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr8:120719177-120779532 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 68.76 cM, cytoband E1
Mapping Data

2 experiments

SNPs within 2kb

1642 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926142	protein coding gene	Chr8:120719177-120779533 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034196	protein coding gene	Chr8:123360867-123427945 (+)
A/J	MGP_AJ_G0034176	protein coding gene	Chr8:118267559-118328227 (+)
AKR/J	MGP_AKRJ_G0034103	protein coding gene	Chr8:121696631-121762358 (+)
BALB/cJ	MGP_BALBcJ_G0034170	protein coding gene	Chr8:118476408-118537277 (+)
C3H/HeJ	MGP_C3HHeJ_G0033881	protein coding gene	Chr8:122429330-122489759 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034690	protein coding gene	Chr8:127474893-127537775 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031632	protein coding gene	Chr8:111157354-111218408 (+)
CAST/EiJ	MGP_CASTEiJ_G0033208	protein coding gene	Chr8:122390192-122453010 (+)
CBA/J	MGP_CBAJ_G0033854	protein coding gene	Chr8:132122525-132189459 (+)
DBA/2J	MGP_DBA2J_G0034010	protein coding gene	Chr8:117488300-117548659 (+)
FVB/NJ	MGP_FVBNJ_G0033953	protein coding gene	Chr8:116542848-116604859 (+)
LP/J	MGP_LPJ_G0034099	protein coding gene	Chr8:123501678-123564386 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034000	protein coding gene	Chr8:134560581-134623077 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034708	protein coding gene	Chr8:121861510-121925523 (+)
PWK/PhJ	MGP_PWKPhJ_G0032910	protein coding gene	Chr8:117247615-117309476 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032750	protein coding gene	Chr8:120559463-120619832 (+)
WSB/EiJ	MGP_WSBEiJ_G0033324	protein coding gene	Chr8:122589830-122653561 (+)

Human Ortholog

CRISPLD2, cysteine rich secretory protein LCCL domain containing 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CRISPLD2, cysteine rich secretory protein LCCL domain containing 2
Synonyms

CRISP11, LCRISP2, LGL1
Links

HGNC:25248

NCBI Gene ID: 83716

neXtProt AC: NX_Q9H0B8

UniProt: Q9H0B8
Chr Location

16q24.1; chr16:84819985-84920768 (+) GRCh38

MGI Vertebrate Homology

Crispld2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CRISPLD2
Gene Tree

Crispld2

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

5
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice show various immunological abnormalities, enhanced glucose tolerance and decreased bone-related measurements.

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All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

793
Tissues

43
cDNA Data

97
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase crispld2

ZFIN crispld2

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All Sequences

56
RefSeq

8
UniProt

1
CCDS

CCDS22714.1, CCDS80939.1

Ensembl

ENSMUSG00000031825 (Evidence)
NCBI Gene

78892

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031825	Ensembl Gene Model \| MGI Sequence Detail	60356	C57BL/6J	± kb
transcript	ENSMUST00000034282	Ensembl \| MGI Sequence Detail	2898	Not Applicable
polypeptide	ENSMUSP00000034282	Ensembl \| MGI Sequence Detail	495	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005881 cysteine-rich secretory protein LCCL domain-containing 2

(term hierarchy)
InterPro Domains

IPR018244 Allergen V5/Tpx-1-related, conserved site

IPR014044 CAP domain

IPR035940 CAP superfamily

IPR051957 Cysteine-rich secretory LCCL domain-containing protein

IPR001283 Cysteine-rich secretory protein-related

IPR004043 LCCL domain

IPR036609 LCCL domain superfamily
GlyGen

Q8BZQ2 1 site

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All nucleic 99

cDNA 98

Primer pair 1

Microarray probesets 4

Summaries

All 46

Developmental Gene Expression 8

Gene Ontology 5

Phenotypes 13
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Crispld2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79727	Chr8:120719239-120719265 (+)	75 bp
Tssr79728	Chr8:120729438-120729449 (+)	10,267 bp
Tssr79729	Chr8:120729459-120729480 (+)	10,293 bp
Tssr2706	Chr8:120768182-120768198 (+)	49,013 bp
Tssr79730	Chr8:120769675-120769683 (+)	50,502 bp
Tssr79731	Chr8:120769701-120769711 (+)	50,529 bp
Tssr79732	Chr8:120776966-120777001 (+)	57,807 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24