Ecrg4 MGI Mouse Gene Detail - MGI:1926146

Symbol

Ecrg4
Name

ECRG4 augurin precursor
Synonyms

1500015O10Rik, augurin

Feature Type

protein coding gene
IDs

MGI:1926146
NCBI Gene: 78896
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:43769762-43781724 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 23.44 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

495 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926146	protein coding gene	Chr1:43769762-43781738 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015981	protein coding gene	Chr1:42759634-42771595 (+)
A/J	MGP_AJ_G0015965	protein coding gene	Chr1:41431700-41443641 (+)
AKR/J	MGP_AKRJ_G0015920	protein coding gene	Chr1:42009712-42023838 (+)
BALB/cJ	MGP_BALBcJ_G0015919	protein coding gene	Chr1:41117358-41129333 (+)
C3H/HeJ	MGP_C3HHeJ_G0015752	protein coding gene	Chr1:42387322-42399283 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016372	protein coding gene	Chr1:44474139-44491033 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014094	protein coding gene	Chr1:38262495-38274205 (+)
CAST/EiJ	MGP_CASTEiJ_G0015333	protein coding gene	Chr1:42393437-42405305 (+)
CBA/J	MGP_CBAJ_G0015724	protein coding gene	Chr1:45794302-45806265 (+)
DBA/2J	MGP_DBA2J_G0015825	protein coding gene	Chr1:40727035-40742028 (+)
FVB/NJ	MGP_FVBNJ_G0015827	protein coding gene	Chr1:40238494-40250477 (+)
LP/J	MGP_LPJ_G0015895	protein coding gene	Chr1:43074026-43085999 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015847	protein coding gene	Chr1:47750062-47762031 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016419	protein coding gene	Chr1:42222325-42235162 (+)
PWK/PhJ	MGP_PWKPhJ_G0015116	protein coding gene	Chr1:40603684-40615769 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014898	protein coding gene	Chr1:42210920-42222732 (+)
WSB/EiJ	MGP_WSBEiJ_G0015395	protein coding gene	Chr1:42262199-42274180 (+)

Human Ortholog

ECRG4, ECRG4 augurin precursor

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ECRG4, ECRG4 augurin precursor
Synonyms

C2orf40
Links

HGNC:24642

NCBI Gene ID: 84417

neXtProt AC: NX_Q9H1Z8

UniProt: Q9H1Z8
Chr Location

2q12.2; chr2:106063241-106078155 (+) GRCh38

MGI Vertebrate Homology

Ecrg4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ECRG4
Gene Tree

Ecrg4

less

Phenotype Summary

12 phenotypes from 3 alleles in 3 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

5
Genomic Mutations

1 involving Ecrg4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice show extended replicative capacity of neural stem cells and enhanced spatial learning and memory.

less

All GO Annotations

26
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

862
Tissues

65
cDNA Data

23
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ecrg4

ZFIN ecrg4a, ecrg4b

less

All Sequences

31
RefSeq

2
UniProt

1
CCDS

CCDS14925.1

Ensembl

ENSMUSG00000026051 (Evidence)
NCBI Gene

78896

			Length	Strain/Species	Flank
genomic	78896	NCBI Gene Model \| MGI Sequence Detail	11963	C57BL/6J	± kb
transcript	NM_024283	RefSeq \| MGI Sequence Detail	888	C57BL/6
polypeptide	Q99LS0	UniProt \| EBI \| MGI Sequence Detail	148	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000060072 augurin

(term hierarchy)
InterPro Domains

IPR028173 Augurin

less

All nucleic 25

cDNA 23

Primer pair 2

Microarray probesets 7

less

MGI:6307132

Summaries

All 51

Developmental Gene Expression 8

Gene Ontology 6

Phenotypes 18
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:358434 Pool KD, et al., ECRG4 mediates host response to cutaneous infection by regulating neutrophil recruitment and adhesion receptor expression. PLoS One. 2024;19(11):e0310810

TSS for Ecrg4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6544	Chr1:43769753-43769793 (+)	11 bp
Tssr6545	Chr1:43769800-43769814 (+)	45 bp
Tssr6546	Chr1:43769826-43769878 (+)	90 bp
Tssr6547	Chr1:43769948-43769959 (+)	192 bp
Tssr6548	Chr1:43769971-43770035 (+)	241 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24