Wrnip1 MGI Mouse Gene Detail - MGI:1926153 - Werner helicase interacting protein 1

Symbol

Wrnip1
Name

Werner helicase interacting protein 1
Synonyms

4833444L21Rik, WHIP

Feature Type

protein coding gene
IDs

MGI:1926153
NCBI Gene: 78903
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr13:32986021-33006592 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 13.74 cM, cytoband A4
Mapping Data

3 experiments

SNPs within 2kb

556 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926153	protein coding gene	Chr13:32986013-33006593 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020426	protein coding gene	Chr13:30805484-30826481 (+)
A/J	MGP_AJ_G0020381	protein coding gene	Chr13:29966415-29986687 (+)
AKR/J	MGP_AKRJ_G0020358	protein coding gene	Chr13:30626898-30647168 (+)
BALB/cJ	MGP_BALBcJ_G0020376	protein coding gene	Chr13:30050966-30071240 (+)
C3H/HeJ	MGP_C3HHeJ_G0020179	protein coding gene	Chr13:30615211-30635485 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020812	protein coding gene	Chr13:31841243-31861663 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018403	protein coding gene	Chr13:28286102-28306691 (+)
CAST/EiJ	MGP_CASTEiJ_G0019696	protein coding gene	Chr13:30325226-30345421 (+)
CBA/J	MGP_CBAJ_G0020135	protein coding gene	Chr13:33214295-33234569 (+)
DBA/2J	MGP_DBA2J_G0020257	protein coding gene	Chr13:29470265-29490762 (+)
FVB/NJ	MGP_FVBNJ_G0020242	protein coding gene	Chr13:29078215-29102538 (+)
LP/J	MGP_LPJ_G0020334	protein coding gene	Chr13:31010453-31030727 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020268	protein coding gene	Chr13:33272360-33294718 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020853	protein coding gene	Chr13:30268936-30290836 (+)
PWK/PhJ	MGP_PWKPhJ_G0019451	protein coding gene	Chr13:29658418-29679292 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019272	protein coding gene	Chr13:29196863-29218541 (+)
WSB/EiJ	MGP_WSBEiJ_G0019758	protein coding gene	Chr13:30592079-30612498 (+)

Human Ortholog

WRNIP1, WRN helicase interacting protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WRNIP1, WRN helicase interacting protein 1
Synonyms

bA420G6.2, CFAP93, FAP93, WHIP
Links

HGNC:20876

NCBI Gene ID: 56897

neXtProt AC: NX_Q96S55

UniProt: Q96S55
Chr Location

6p25.2; chr6:2765393-2786952 (+) GRCh38

MGI Vertebrate Homology

Wrnip1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WRNIP1
Gene Tree

Wrnip1

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

4
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Wrnip1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

32
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

763
Tissues

31
cDNA Data

12
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase wrnip1

ZFIN wrnip1

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All Sequences

57
RefSeq

2
UniProt

2
CCDS

CCDS26427.1

Ensembl

ENSMUSG00000021400 (Evidence)
NCBI Gene

78903

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021400	Ensembl Gene Model \| MGI Sequence Detail	20572	C57BL/6J	± kb
transcript	ENSMUST00000021832	Ensembl \| MGI Sequence Detail	2633	Not Applicable
polypeptide	ENSMUSP00000021832	Ensembl \| MGI Sequence Detail	660	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000017456 ATPase WRNIP1

(term hierarchy)
EC

3.6.1.-
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR051314 AAA ATPase RarA/MGS1/WRNIP1

IPR032423 AAA C-terminal domain

IPR003959 ATPase, AAA-type, core

IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal

IPR021886 MgsA AAA+ ATPase C-terminal

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR006642 Rad18, zinc finger UBZ4-type

IPR040539 WRNIP1, ubiquitin-binding domain
GlyGen

Q91XU0 1 site, 1 N-linked glycan (1 site)

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All nucleic 16

Genomic 3

cDNA 13

Microarray probesets 2

Summaries

All 50

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 22
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Wrnip1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119151	Chr13:32985990-32986135 (+)	42 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24