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Atf6 Gene Detail
Summary
  • Symbol
    Atf6
  • Name
    activating transcription factor 6
  • Synonyms
    9130025P16Rik, Atf6alpha, ESTM49
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926157
    NCBI Gene: 226641
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:170532243-170695340 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 76.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4243 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926157
 protein coding gene Chr1:170532026-170696414 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016733
 protein coding gene Chr1:176430602-176614305 (-)
A/J MGP_AJ_G0016713
 protein coding gene Chr1:169242102-169418485 (-)
AKR/J MGP_AKRJ_G0016679
 protein coding gene Chr1:174302476-174485528 (-)
BALB/cJ MGP_BALBcJ_G0016674
 protein coding gene Chr1:169711605-169873917 (-)
C3H/HeJ MGP_C3HHeJ_G0016497
 protein coding gene Chr1:174560648-174740964 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017135
 protein coding gene Chr1:182263895-182442256 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014844
 protein coding gene Chr1:160959568-161129366 (-)
CAST/EiJ MGP_CASTEiJ_G0016078
 protein coding gene Chr1:174195480-174378034 (-)
CBA/J MGP_CBAJ_G0016472
 protein coding gene Chr1:188761038-188945325 (-)
DBA/2J MGP_DBA2J_G0016579
 protein coding gene Chr1:168091588-168255880 (-)
FVB/NJ MGP_FVBNJ_G0016576
 protein coding gene Chr1:166453387-166625469 (-)
LP/J MGP_LPJ_G0016650
 protein coding gene Chr1:177552131-177733354 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016602
 protein coding gene Chr1:196080286-196263085 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017172
 protein coding gene Chr1:174212827-174388729 (-)
PWK/PhJ MGP_PWKPhJ_G0015864
 protein coding gene Chr1:167331608-167508748 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015648
 protein coding gene Chr1:172960570-173137941 (-)
WSB/EiJ MGP_WSBEiJ_G0016140
 protein coding gene Chr1:174327601-174507624 (-)



Homology
more
  • Human Ortholog
    ATF6, activating transcription factor 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATF6, activating transcription factor 6
  • Synonyms
    ACHM7, ATF6A, ATP6alpha
  • Links
    NCBI Gene ID: 22926
    neXtProt AC: NX_P18850
    UniProt: P18850

  • Chr Location
    1q23.3; chr1:161766298-161977574 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Atf6 mouse models; 1 with human ATF6 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased sensitivity to dithiothreitol, thapsigargin, and tunicamycin. Mice homozygous for a conditional allele activated in islet cells exhibit reduced sensitivity to TUDCA.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    888
  • Tissues
    145
  • cDNA Data
    102
  • Literature Summary
    41
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026663 Ensembl Gene Model | MGI Sequence Detail 163098 C57BL/6J ±  kb
    transcript ENSMUST00000027974 Ensembl | MGI Sequence Detail 7246 Not Applicable  
    polypeptide ENSMUSP00000027974 Ensembl | MGI Sequence Detail 656 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000004402 cyclic AMP-dependent transcription factor ATF-6 alpha
      (term hierarchy)
    • InterPro Domains
      IPR051882 ATF bZIP Transcription Factors
      IPR004827 Basic-leucine zipper domain
      IPR046347 Basic-leucine zipper domain superfamily
    • GlyGen
      F6VAN0 4 sites, 5 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 110
      cDNA 102
      Primer pair 7
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1334425
    References
    more
    • Summaries
      All 169
      Developmental Gene Expression 41
      Diseases 1
      Gene Ontology 12
      Phenotypes 66
    • Earliest
      J:52606 Eddleston J, et al., Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Genomics. 1999 Mar 1;56(2):149-59
    • Latest
      J:353791 Xu L, et al., Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells. Cell Stem Cell. 2024 Aug 16;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory