Fndc8 Gene Detail

Summary

• Symbol
  Fndc8
• Name
  fibronectin type III domain containing 8
• Synonyms
  4930466G16Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1926169
  NCBI Gene: 78919
• Alliance
  gene page
• Transcription Start Sites
  2 TSS

Location &
Maps

• Sequence Map
  Chr11:82782971-82791563 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, 50.30 cM, cytoband B5
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  281 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926169	protein coding gene	Chr11:82782950-82791627 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018833	protein coding gene	Chr11:84174952-84189854 (+)
A/J	MGP_AJ_G0018800	protein coding gene	Chr11:80940916-80950271 (+)
AKR/J	MGP_AKRJ_G0018770	protein coding gene	Chr11:83367690-83381103 (+)
BALB/cJ	MGP_BALBcJ_G0018773	protein coding gene	Chr11:81344882-81353994 (+)
C3H/HeJ	MGP_C3HHeJ_G0018587	protein coding gene	Chr11:83402721-83411274 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019225	protein coding gene	Chr11:86696595-86707960 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016859	protein coding gene	Chr11:77904719-77913516 (+)
CAST/EiJ	MGP_CASTEiJ_G0018142	protein coding gene	Chr11:83991057-84000768 (+)
CBA/J	MGP_CBAJ_G0018558	protein coding gene	Chr11:90451511-90461650 (+)
DBA/2J	MGP_DBA2J_G0018666	protein coding gene	Chr11:80516078-80524927 (+)
FVB/NJ	MGP_FVBNJ_G0018655	protein coding gene	Chr11:80041329-80050351 (+)
LP/J	MGP_LPJ_G0018736	protein coding gene	Chr11:84689975-84699551 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018682	protein coding gene	Chr11:90648629-90658117 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019265	protein coding gene	Chr11:83630270-83640182 (+)
PWK/PhJ	MGP_PWKPhJ_G0017912	protein coding gene	Chr11:81337308-81346543 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017703	protein coding gene	Chr11:83253329-83262047 (+)
WSB/EiJ	MGP_WSBEiJ_G0018194	protein coding gene	Chr11:83516456-83526773 (+)

Homology

• Human Ortholog
  FNDC8, fibronectin type III domain containing 8

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  FNDC8, fibronectin type III domain containing 8
  
• Links
  HGNC:25286

  NCBI Gene ID: 54752

  neXtProt AC: NX_Q8TC99

  UniProt: Q8TC99

  
  
• Chr Location
  17q12; chr17:35121615-35130732 (+)  GRCh38

---

• MGI Vertebrate Homology
  Fndc8 stringent orthology
  1 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: FNDC8
• Gene Tree
  Fndc8
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  12 phenotype references
  

• All Mutations and Alleles
  4
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Gene trapped
  1
• Targeted
  1
• Genomic Mutations
  2 involving Fndc8
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  18 strains or lines available

Male mice homozygous for a null allele exhibit normal fecundity.

Gene Ontology
(GO)
Classifications

Expression

• Assay Results
  706
• cDNA Data
  7

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  30
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS25151.1

• Ensembl
  ENSMUSG00000018844 (Evidence)
• NCBI Gene
  78919

Representative Sequences			Length	Strain/Species
genomic	78919	NCBI Gene Model | MGI Sequence Detail	8593	C57BL/6J
transcript	NM_030224	RefSeq | MGI Sequence Detail	2081	Not Specified
polypeptide	Q9D2H8	UniProt | EBI | MGI Sequence Detail	321	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000031251 fibronectin type III domain-containing protein 8
  (term hierarchy)
• InterPro Domains
  IPR003961 Fibronectin type III
  IPR036116 Fibronectin type III superfamily
  IPR013783 Immunoglobulin-like fold

Molecular
Reagents

• All nucleic 7

  cDNA 7

  
  

  Microarray probesets 2

References

• Summaries
  All 28

  Phenotypes 12
• Earliest
  J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
• Latest
  J:279039 Lu Y, et al., CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice. Biol Reprod. 2019 Aug 1;101(2):501-511

TSS for Fndc8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103586	Chr11:82782942-82782954 (+)	-23 bp
Tssr3604	Chr11:82782955-82782961 (+)	-13 bp