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Polr3h Gene Detail
Summary
  • Symbol
    Polr3h
  • Name
    polymerase (RNA) III (DNA directed) polypeptide H
  • Synonyms
    5031409G22Rik, RPC8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926179
    NCBI Gene: 78929
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:81799231-81813824 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 38.26 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    540 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926179
 protein coding gene Chr15:81772429-81813824 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022125
 protein coding gene Chr15:82388884-82400849 (-)
A/J MGP_AJ_G0022086
 protein coding gene Chr15:79479171-79490413 (-)
AKR/J MGP_AKRJ_G0022061
 protein coding gene Chr15:81672431-81685747 (-)
BALB/cJ MGP_BALBcJ_G0022092
 protein coding gene Chr15:79518480-79529447 (-)
C3H/HeJ MGP_C3HHeJ_G0021863
 protein coding gene Chr15:81698807-81709965 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022535
 protein coding gene Chr15:85622572-85633759 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020063
 protein coding gene Chr15:75925226-75936936 (-)
CAST/EiJ MGP_CASTEiJ_G0021382
 protein coding gene Chr15:82478059-82491241 (-)
CBA/J MGP_CBAJ_G0021827
 protein coding gene Chr15:88284117-88295309 (-)
DBA/2J MGP_DBA2J_G0021957
 protein coding gene Chr15:78950814-78961781 (-)
FVB/NJ MGP_FVBNJ_G0021934
 protein coding gene Chr15:77990948-78002134 (-)
LP/J MGP_LPJ_G0022025
 protein coding gene Chr15:82533014-82544221 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021955
 protein coding gene Chr15:93216683-93228920 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022549
 protein coding gene Chr15:81774721-81787132 (-)
PWK/PhJ MGP_PWKPhJ_G0021125
 protein coding gene Chr15:78994369-79006601 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020964
 protein coding gene Chr15:81564597-81575853 (-)
WSB/EiJ MGP_WSBEiJ_G0021435
 protein coding gene Chr15:82191973-82204983 (-)



Homology
more
  • Human Ortholog
    POLR3H, RNA polymerase III subunit H
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLR3H, RNA polymerase III subunit H
  • Synonyms
    C25, RPC22.9, RPC8
  • Links
    NCBI Gene ID: 171568
    neXtProt AC: NX_Q9Y535
    UniProt: Q9Y535

  • Chr Location
    22q13.2; chr22:41525799-41544606 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Polr3h mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 1 genetic background
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die before E10. Mice with a point mutation (p.D50G) show delayed pubertal development, with late first estrus or preputial separation, decreased fertility later in life, small litter size and decreased antral and primary follicles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    805
  • Tissues
    99
  • cDNA Data
    10
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 78929 NCBI Gene Model | MGI Sequence Detail 14594 C57BL/6J ±  kb
    transcript NM_030229 RefSeq | MGI Sequence Detail 2514 C57BL/6  
    polypeptide Q9D2C6 UniProt | EBI | MGI Sequence Detail 204 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000013008 DNA-directed RNA polymerase III subunit RPC8
      (term hierarchy)
    • InterPro Domains
      IPR004519 DNA-directed RNA polymerase, subunit E/RPC8
      IPR012340 Nucleic acid-binding, OB-fold
      IPR013238 RNA polymerase III, subunit Rpc25
      IPR005576 RNA polymerase Rpb7-like , N-terminal
      IPR036898 RNA polymerase Rpb7-like, N-terminal domain superfamily
      IPR045113 RNA polymerase subunit Rpb7-like
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 6
      Phenotypes 28
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory