Wdr76 MGI Mouse Gene Detail - MGI:1926186

Symbol

Wdr76
Name

WD repeat domain 76
Synonyms

5830411K18Rik

Feature Type

protein coding gene
IDs

MGI:1926186
NCBI Gene: 241627
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:121337204-121375341 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 60.41 cM, cytoband F1
Mapping Data

3 experiments

SNPs within 2kb

979 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926186	protein coding gene	Chr2:121337204-121375341 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026398	protein coding gene	Chr2:124381214-124472806 (+)
A/J	MGP_AJ_G0026359	protein coding gene	Chr2:119337492-119390006 (+)
AKR/J	MGP_AKRJ_G0026337	protein coding gene	Chr2:122709716-122755913 (+)
BALB/cJ	MGP_BALBcJ_G0026371	protein coding gene	Chr2:119524758-119625351 (+)
C3H/HeJ	MGP_C3HHeJ_G0026117	protein coding gene	Chr2:123175345-123212922 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026819	protein coding gene	Chr2:128492197-128539460 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024197	protein coding gene	Chr2:114365474-114398920 (+)
CAST/EiJ	MGP_CASTEiJ_G0025579	protein coding gene	Chr2:123509919-123545211 (+)
CBA/J	MGP_CBAJ_G0026095	protein coding gene	Chr2:132978128-133037479 (+)
DBA/2J	MGP_DBA2J_G0026232	protein coding gene	Chr2:118749732-118796648 (+)
FVB/NJ	MGP_FVBNJ_G0026195	protein coding gene	Chr2:117561834-117602378 (+)
LP/J	MGP_LPJ_G0026334	protein coding gene	Chr2:124684397-124729332 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026214	protein coding gene	Chr2:137200684-137292487 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026874	protein coding gene	Chr2:122808847-122857107 (+)
PWK/PhJ	MGP_PWKPhJ_G0025315	protein coding gene	Chr2:118361965-118403900 (+)
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0025649	protein coding gene	Chr2:123657025-123697844 (+)

Human Ortholog

WDR76, WD repeat domain 76

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WDR76, WD repeat domain 76
Synonyms

CDW14, CMR1
Links

HGNC:25773

NCBI Gene ID: 79968

neXtProt AC: NX_Q9H967

UniProt: Q9H967
Chr Location

15q15.3; chr15:43826980-43868412 (+) GRCh38

MGI Vertebrate Homology

Wdr76 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WDR76
Gene Tree

Wdr76

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

All Mutations and Alleles

115
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

111
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Wdr76
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

50 strains or lines available

Mice homozygous for a knock-out allele are viable and fertile with no apparent developmental abnormalities.

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All GO Annotations

13
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

27

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase wdr76

ZFIN wdr76

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All Sequences

53
RefSeq

11
UniProt

2
CCDS

CCDS38218.1, CCDS89546.1

Ensembl

ENSMUSG00000027242 (Evidence)
NCBI Gene

241627

			Length	Strain/Species	Flank
genomic	241627	NCBI Gene Model \| MGI Sequence Detail	38138	C57BL/6J	± kb
transcript	NM_001369185	RefSeq \| MGI Sequence Detail	5547	C57BL/6
polypeptide	A6PWY4	UniProt \| EBI \| MGI Sequence Detail	622	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031728 WD repeat-containing protein 76

(term hierarchy)
InterPro Domains

IPR001680 WD40 repeat

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

IPR050853 WD repeat-containing DNA damage-binding protein

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All nucleic 27

cDNA 27

Microarray probesets 4

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MGI:2138785

Summaries

All 38

Gene Ontology 4

Phenotypes 11
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Wdr76:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19775	Chr2:121337183-121337190 (+)	-17 bp
Tssr19776	Chr2:121337196-121337214 (+)	1 bp
Tssr19777	Chr2:121337229-121337273 (+)	47 bp
Tssr19778	Chr2:121340300-121340327 (+)	3,110 bp
Tssr19779	Chr2:121340337-121340343 (+)	3,136 bp
Tssr19780	Chr2:121374920-121374925 (+)	37,719 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24