Tnip1 MGI Mouse Gene Detail - MGI:1926194 - TNFAIP3 interacting protein 1

Symbol

Tnip1
Name

TNFAIP3 interacting protein 1
Synonyms

A20-binding inhibitor of NF-kappa B activation, ABIN1, Nef, VAN

Feature Type

protein coding gene
IDs

MGI:1926194
NCBI Gene: 57783
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr11:54801611-54853743 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 32.13 cM
Mapping Data

1 experiment

SNPs within 2kb

1505 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926194	protein coding gene	Chr11:54801611-54853766 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018322	protein coding gene	Chr11:54402139-54457502 (-)
A/J	MGP_AJ_G0018291	protein coding gene	Chr11:52376178-52430950 (-)
AKR/J	MGP_AKRJ_G0018260	protein coding gene	Chr11:54092160-54148216 (-)
BALB/cJ	MGP_BALBcJ_G0018262	protein coding gene	Chr11:52719864-52772234 (-)
C3H/HeJ	MGP_C3HHeJ_G0018073	protein coding gene	Chr11:54030017-54087404 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018714	protein coding gene	Chr11:56064349-56117312 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016364	protein coding gene	Chr11:49811848-49864050 (-)
CAST/EiJ	MGP_CASTEiJ_G0017638	protein coding gene	Chr11:54072006-54126148 (-)
CBA/J	MGP_CBAJ_G0018048	protein coding gene	Chr11:58722421-58786376 (-)
DBA/2J	MGP_DBA2J_G0018157	protein coding gene	Chr11:52081566-52133525 (-)
FVB/NJ	MGP_FVBNJ_G0018149	protein coding gene	Chr11:51736072-51792945 (-)
LP/J	MGP_LPJ_G0018232	protein coding gene	Chr11:54855677-54911271 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018175	protein coding gene	Chr11:59934276-59987913 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018756	protein coding gene	Chr11:54103301-54156491 (-)
PWK/PhJ	MGP_PWKPhJ_G0017411	protein coding gene	Chr11:52625152-52683899 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017206	protein coding gene	Chr11:53896327-53949891 (-)
WSB/EiJ	MGP_WSBEiJ_G0017686	protein coding gene	Chr11:53749789-53802172 (-)

Human Ortholog

TNIP1, TNFAIP3 interacting protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TNIP1, TNFAIP3 interacting protein 1
Synonyms

ABIN-1, NAF1, nip40-1, VAN
Links

HGNC:16903

NCBI Gene ID: 10318

neXtProt AC: NX_Q15025

UniProt: Q15025
Chr Location

5q33.1; chr5:151029943-151093577 (-) GRCh38

MGI Vertebrate Homology

Tnip1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TNIP1
Gene Tree

Tnip1

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References

1 with disease annotations

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Phenotype Summary

95 phenotypes from 7 alleles in 6 genetic backgrounds
16 phenotypes from multigenic genotypes
3 images
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

72
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

56
Targeted

11
Genomic Mutations

2 involving Tnip1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

57 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit perinatal lethality associated with anemia and focal apoptosis in the fetal liver. Mice homozygous for a gene trap allele exhibit partial prenatal lethality and SLE-like inflammatory disease.

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All GO Annotations

29
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

803
Tissues

38
cDNA Data

74
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tnip1

ZFIN tnip1

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All Sequences

122
RefSeq

28
UniProt

7
CCDS

CCDS24704.1, CCDS56769.1, CCDS70188.1

Ensembl

ENSMUSG00000020400 (Evidence)
NCBI Gene

57783

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020400	Ensembl Gene Model \| MGI Sequence Detail	52133	C57BL/6J	± kb
transcript	ENSMUST00000018482	Ensembl \| MGI Sequence Detail	2810	Not Applicable
polypeptide	ENSMUSP00000018482	Ensembl \| MGI Sequence Detail	647	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000016492 TNFAIP3-interacting protein 1

(term hierarchy)
PDB

6N5M, 6N6R, 6N6S
InterPro Domains

IPR032419 NF-kappa-B essential modulator NEMO, CC2-LZ domain
GlyGen

Q9WUU8 8 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (7 sites)

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All nucleic 74

cDNA 74

Microarray probesets 3

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MGI:2144384

Summaries

All 68

Developmental Gene Expression 4

Diseases 1

Gene Ontology 10

Phenotypes 32
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:358400 Medhavy A, et al., A TNIP1-driven systemic autoimmune disorder with elevated IgG4. Nat Immunol. 2024 Sep;25(9):1678-1691

TSS for Tnip1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr108031	Chr11:54853729-54853779 (-)	-11 bp
Tssr108030	Chr11:54853699-54853700 (-)	43 bp
Tssr108029	Chr11:54846875-54846941 (-)	6,835 bp
Tssr108028	Chr11:54846859-54846866 (-)	6,880 bp
Tssr108027	Chr11:54843248-54843254 (-)	10,492 bp
Tssr108026	Chr11:54809477-54809509 (-)	44,250 bp
Tssr108025	Chr11:54808714-54808726 (-)	45,023 bp
Tssr108024	Chr11:54807777-54807792 (-)	45,958 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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