Fibp MGI Mouse Gene Detail - MGI:1926233 - fibroblast growth factor (acidic) intracellular binding protein

Symbol

Fibp
Name

fibroblast growth factor (acidic) intracellular binding protein
Synonyms

2010004G08Rik, 2010005N21Rik, 3010027N18Rik

Feature Type

protein coding gene
IDs

MGI:1926233
NCBI Gene: 58249
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr19:5510643-5515079 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 4.33 cM, cytoband A
Mapping Data

2 experiments

SNPs within 2kb

194 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926233	protein coding gene	Chr19:5510626-5515080 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024708	protein coding gene	Chr19:2429845-2434294 (+)
A/J	MGP_AJ_G0024674	protein coding gene	Chr19:2295255-2299702 (+)
AKR/J	MGP_AKRJ_G0024647	protein coding gene	Chr19:2353164-2357612 (+)
BALB/cJ	MGP_BALBcJ_G0024674	protein coding gene	Chr19:2289009-2293457 (+)
C3H/HeJ	MGP_C3HHeJ_G0024442	protein coding gene	Chr19:2362728-2367175 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025121	protein coding gene	Chr19:2485436-2489886 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022551	protein coding gene	Chr19:2197614-2202308 (+)
CAST/EiJ	MGP_CASTEiJ_G0023914	protein coding gene	Chr19:2390190-2394618 (+)
CBA/J	MGP_CBAJ_G0024414	protein coding gene	Chr19:2594829-2599280 (+)
DBA/2J	MGP_DBA2J_G0024541	protein coding gene	Chr19:2274634-2279087 (+)
FVB/NJ	MGP_FVBNJ_G0024508	protein coding gene	Chr19:2281409-2285858 (+)
LP/J	MGP_LPJ_G0024627	protein coding gene	Chr19:2409309-2413759 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024538	protein coding gene	Chr19:2449505-2453945 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025169	protein coding gene	Chr19:2370982-2375432 (+)
PWK/PhJ	MGP_PWKPhJ_G0023660	protein coding gene	Chr19:2311662-2316168 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023465	protein coding gene	Chr19:2355737-2360096 (+)
WSB/EiJ	MGP_WSBEiJ_G0023976	protein coding gene	Chr19:2381895-2386350 (+)

Human Ortholog

FIBP, FGF1 intracellular binding protein

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FIBP, FGF1 intracellular binding protein
Synonyms

FGFIBP, FIBP-1, TROFAS
Links

HGNC:3705

NCBI Gene ID: 9158

neXtProt AC: NX_O43427

UniProt: O43427
Chr Location

11q13.1; chr11:65883740-65888531 (-) GRCh38

MGI Vertebrate Homology

Fibp stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FIBP
Gene Tree

Fibp

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Gene trapped

6
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

71

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fibp

ZFIN fibpa, fibpb

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All Sequences

61
RefSeq

8
UniProt

4
CCDS

CCDS57130.1, CCDS89310.1

Ensembl

ENSMUSG00000024911 (Evidence)
NCBI Gene

58249

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024911	Ensembl Gene Model \| MGI Sequence Detail	4437	C57BL/6J	± kb
transcript	ENSMUST00000025847	Ensembl \| MGI Sequence Detail	1215	Not Applicable
polypeptide	ENSMUSP00000025847	Ensembl \| MGI Sequence Detail	364	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000007519 acidic fibroblast growth factor intracellular-binding protein

(term hierarchy)
InterPro Domains

IPR008614 Acidic fibroblast growth factor intracellular-binding protein
GlyGen

Q9JI19 1 site, 1 N-linked glycan (1 site)

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All nucleic 72

cDNA 72

Microarray probesets 4

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MGI:1913680, MGI:1924201, MGI:1924334

Summaries

All 30

Gene Ontology 4

Phenotypes 7
Earliest

J:66718 Kolpakova E, et al., Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein. Biochem J. 2000 Dec 15;352 Pt 3:629-35
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fibp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154426	Chr19:5510636-5510666 (+)	8 bp
Tssr154427	Chr19:5510676-5510683 (+)	37 bp
Tssr5412	Chr19:5510687-5510694 (+)	48 bp
Tssr154428	Chr19:5514085-5514136 (+)	3,468 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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