Wtap MGI Mouse Gene Detail - MGI:1926395

Symbol

Wtap
Name

WT1 associating protein
Synonyms

2810408K05Rik, 9430038B09Rik

Feature Type

protein coding gene
IDs

MGI:1926395
NCBI Gene: 60532
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr17:13185686-13211430 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 8.73 cM
Mapping Data

3 experiments

SNPs within 2kb

561 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926395	protein coding gene	Chr17:13185683-13213056 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023157	protein coding gene	Chr17:10657812-10699257 (-)
A/J	MGP_AJ_G0023125	protein coding gene	Chr17:10473894-10505902 (-)
AKR/J	MGP_AKRJ_G0023089	protein coding gene	Chr17:10316956-10370374 (-)
BALB/cJ	MGP_BALBcJ_G0023125	protein coding gene	Chr17:10259330-10287427 (-)
C3H/HeJ	MGP_C3HHeJ_G0022887	protein coding gene	Chr17:10562981-10589426 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023567	protein coding gene	Chr17:11050765-11077736 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021040	protein coding gene	Chr17:3960025-3984793 (+)
CAST/EiJ	MGP_CASTEiJ_G0022401	protein coding gene	Chr17:10650582-10684140 (-)
CBA/J	MGP_CBAJ_G0022860	protein coding gene	Chr17:11481243-11506600 (-)
DBA/2J	MGP_DBA2J_G0022992	protein coding gene	Chr17:10112468-10143555 (-)
FVB/NJ	MGP_FVBNJ_G0022963	protein coding gene	Chr17:10046490-10073352 (-)
LP/J	MGP_LPJ_G0023064	protein coding gene	Chr17:10507280-10538729 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022982	protein coding gene	Chr17:11109165-11134039 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023594	protein coding gene	Chr17:10588194-10618420 (-)
PWK/PhJ	MGP_PWKPhJ_G0022148	protein coding gene	Chr17:9809192-9838017 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021980	protein coding gene	Chr17:10012144-10040963 (-)
WSB/EiJ	MGP_WSBEiJ_G0022459	protein coding gene	Chr17:10906884-10934693 (-)

Human Ortholog

WTAP, WT1 associated protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WTAP, WT1 associated protein
Synonyms

Mum2
Links

HGNC:16846

NCBI Gene ID: 9589

neXtProt AC: NX_Q15007

UniProt: Q15007
Chr Location

6q25.3; chr6:159725585-159756319 (+) GRCh38

MGI Vertebrate Homology

Wtap stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WTAP
Gene Tree

Wtap

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

161
Endonuclease-mediated

5
Gene trapped

152
Targeted

4
Genomic Mutations

1 involving Wtap
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

83 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a mutation display lethality during embryogenesis with abnormalities appearing during gastrulation.

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All GO Annotations

23
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

768
Tissues

36
cDNA Data

12
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase wtap

ZFIN wtap

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All Sequences

69
RefSeq

8
UniProt

7
CCDS

CCDS49949.1, CCDS49950.1

Ensembl

ENSMUSG00000060475 (Evidence)
NCBI Gene

60532

			Length	Strain/Species	Flank
genomic	60532	NCBI Gene Model \| MGI Sequence Detail	25745	C57BL/6J	± kb
transcript	NM_175394	RefSeq \| MGI Sequence Detail	4967	C57BL/6
polypeptide	Q9ER69	UniProt \| EBI \| MGI Sequence Detail	396	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000017460 pre-mRNA-splicing regulator WTAP

(term hierarchy)
InterPro Domains

IPR033757 Pre-mRNA-splicing regulator WTAP
GlyGen

Q9ER69 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 17

cDNA 14

Primer pair 3

Microarray probesets 6

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MGI:1922064, MGI:1924525

Summaries

All 60

Developmental Gene Expression 9

Gene Ontology 11

Phenotypes 26
Earliest

J:6493 Sakano H, et al., Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes. Nature. 1981 Apr 16;290(5807):562-5
Latest

J:355331 Mao Y, et al., Advanced paternal age exacerbates neuroinflammation in offspring via m6A modification-mediated intergenerational inheritance. J Neuroinflammation. 2024 Oct 4;21(1):249

TSS for Wtap:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr146476	Chr17:13213054-13213058 (-)	-1,626 bp
Tssr146475	Chr17:13211490-13211535 (-)	-83 bp
Tssr146474	Chr17:13211472-13211485 (-)	-49 bp
Tssr146473	Chr17:13211374-13211441 (-)	22 bp
Tssr146472	Chr17:13211114-13211136 (-)	305 bp
Tssr146471	Chr17:13211075-13211113 (-)	336 bp
Tssr146470	Chr17:13211059-13211073 (-)	364 bp
Tssr146469	Chr17:13210432-13210435 (-)	996 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24