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Fancg Gene Detail
Summary
  • Symbol
    Fancg
  • Name
    Fanconi anemia, complementation group G
  • Synonyms
    Xrcc9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926471
    NCBI Gene: 60534
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:43002343-43010506 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 22.97 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    332 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926471
 protein coding gene Chr4:43002337-43010565 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028197
 protein coding gene Chr4:41083310-41091391 (-)
A/J MGP_AJ_G0028153
 protein coding gene Chr4:39642108-39650192 (-)
AKR/J MGP_AKRJ_G0028105
 protein coding gene Chr4:40546857-40554930 (-)
BALB/cJ MGP_BALBcJ_G0028173
 protein coding gene Chr4:39732523-39740687 (-)
C3H/HeJ MGP_C3HHeJ_G0027895
 protein coding gene Chr4:41169895-41177982 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028614
 protein coding gene Chr4:42614873-42623039 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025926
 protein coding gene Chr4:37105977-37114210 (-)
CAST/EiJ MGP_CASTEiJ_G0027335
 protein coding gene Chr4:40643500-40651917 (-)
CBA/J MGP_CBAJ_G0027861
 protein coding gene Chr4:43954276-43962363 (-)
DBA/2J MGP_DBA2J_G0028010
 protein coding gene Chr4:39558079-39566175 (-)
FVB/NJ MGP_FVBNJ_G0027977
 protein coding gene Chr4:38779703-38787784 (-)
LP/J MGP_LPJ_G0028109
 protein coding gene Chr4:41149660-41159166 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028001
 protein coding gene Chr4:47214055-47232564 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028650
 protein coding gene Chr4:40738982-40747085 (-)
PWK/PhJ MGP_PWKPhJ_G0027061
 protein coding gene Chr4:39589978-39598570 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026887
 protein coding gene Chr4:40294143-40302236 (-)
WSB/EiJ MGP_WSBEiJ_G0027415
 protein coding gene Chr4:40648097-40656177 (-)



Homology
more
  • Human Ortholog
    FANCG, FA complementation group G
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FANCG, FA complementation group G
  • Synonyms
    FAG, XRCC9
  • Links
    NCBI Gene ID: 2189
    neXtProt AC: NX_O15287
    UniProt: O15287

  • Chr Location
    9p13.3; chr9:35073835-35080004 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human FANCG associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Females and males homozygous for targeted null mutations exhibit hypogonadism and reduced fertility. Cytogeneic analysis showed somatic chromosome aberrations occur at a higher spontaneous rate and are easier to induce than in normal cells. Cells are also more sensitive to mitomycin C.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    717
  • Tissues
    10
  • cDNA Data
    32
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028453 Ensembl Gene Model | MGI Sequence Detail 8164 C57BL/6J ±  kb
    transcript ENSMUST00000030165 Ensembl | MGI Sequence Detail 2771 Not Applicable  
    polypeptide ENSMUSP00000030165 Ensembl | MGI Sequence Detail 623 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 32
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2140478
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 27
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:338032 Shah R, et al., A C57BL/6J Fancg-KO Mouse Model Generated by CRISPR/Cas9 Partially Captures the Human Phenotype. Int J Mol Sci. 2023 Jul 5;24(13)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory