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Mapk8ip2 Gene Detail
Summary
  • Symbol
    Mapk8ip2
  • Name
    mitogen-activated protein kinase 8 interacting protein 2
  • Synonyms
    3230402N03Rik, IB2, Jip2, JNK-interacting protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926555
    NCBI Gene: 60597
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:89338114-89346650 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 44.92 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    197 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926555
 protein coding gene Chr15:89338114-89348671 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022237
 protein coding gene Chr15:90653044-90666034 (+)
A/J MGP_AJ_G0022196
 protein coding gene Chr15:87185873-87196278 (+)
AKR/J MGP_AKRJ_G0022171
 protein coding gene Chr15:89769492-89781596 (+)
BALB/cJ MGP_BALBcJ_G0022202
 protein coding gene Chr15:87289261-87300240 (+)
C3H/HeJ MGP_C3HHeJ_G0021972
 protein coding gene Chr15:89767155-89777714 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022647
 protein coding gene Chr15:93949398-93961566 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020172
 protein coding gene Chr15:83408415-83418546 (+)
CAST/EiJ MGP_CASTEiJ_G0021494
 protein coding gene Chr15:90551620-90564432 (+)
CBA/J MGP_CBAJ_G0021939
 protein coding gene Chr15:97138620-97149130 (+)
DBA/2J MGP_DBA2J_G0022066
 protein coding gene Chr15:86635249-86645614 (+)
FVB/NJ MGP_FVBNJ_G0022045
 protein coding gene Chr15:85700119-85717344 (+)
LP/J MGP_LPJ_G0022137
 protein coding gene Chr15:90812822-90825529 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022065
 protein coding gene Chr15:101533966-101544504 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022662
 protein coding gene Chr15:89805256-89815786 (+)
PWK/PhJ MGP_PWKPhJ_G0021235
 protein coding gene Chr15:86697390-86708310 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021069
 protein coding gene Chr15:89555227-89566072 (+)
WSB/EiJ MGP_WSBEiJ_G0021543
 protein coding gene Chr15:90293827-90318743 (+)



Homology
more
  • Human Ortholog
    MAPK8IP2, mitogen-activated protein kinase 8 interacting protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAPK8IP2, mitogen-activated protein kinase 8 interacting protein 2
  • Synonyms
    IB-2, IB2, JIP2, PRKM8IPL
  • Links
    NCBI Gene ID: 23542
    neXtProt AC: NX_Q13387
    UniProt: Q13387

  • Chr Location
    22q13.33; chr22:50600793-50613981 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are smaller in size and exhibit male infertility. Mice homozygous for a different knock-out allele exhibit behavioral and cerebellar transmission deficits.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1033
  • Tissues
    147
  • cDNA Data
    11
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 60597 NCBI Gene Model | MGI Sequence Detail 8537 C57BL/6J ±  kb
    transcript NM_021921 RefSeq | MGI Sequence Detail 3553 C57BL/6  
    polypeptide Q9ERE9 UniProt | EBI | MGI Sequence Detail 830 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 12
      Primer pair 1
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1914671, MGI:2146077, MGI:2146184, MGI:2146319
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 13
      Phenotypes 29
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:344870 Zhou Y, et al., beta-Cell miRNA-503-5p Induced by Hypomethylation and Inflammation Promotes Insulin Resistance and beta-Cell Decompensation. Diabetes. 2024 Jan 1;73(1):57-74
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory