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Gucy1a1 Gene Detail
Summary
  • Symbol
    Gucy1a1
  • Name
    guanylate cyclase 1, soluble, alpha 1
  • Synonyms
    1200016O07Rik, alpha 1 sGC, Gucy1a3, sGC-alpha1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926562
    NCBI Gene: 60596
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:81999734-82053096 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 35.97 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1759 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926562
 protein coding gene Chr3:81999734-82053253 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027326
 protein coding gene Chr3:81889754-81946551 (-)
A/J MGP_AJ_G0027288
 protein coding gene Chr3:79181643-79240233 (-)
AKR/J MGP_AKRJ_G0027256
 protein coding gene Chr3:81047951-81102529 (-)
BALB/cJ MGP_BALBcJ_G0027299
 protein coding gene Chr3:79280322-79334254 (-)
C3H/HeJ MGP_C3HHeJ_G0027043
 protein coding gene Chr3:81338870-81393629 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027745
 protein coding gene Chr3:84999540-85052711 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025098
 protein coding gene Chr3:74948052-75002016 (-)
CAST/EiJ MGP_CASTEiJ_G0026490
 protein coding gene Chr3:81517297-81580218 (-)
CBA/J MGP_CBAJ_G0027018
 protein coding gene Chr3:87838158-87894902 (-)
DBA/2J MGP_DBA2J_G0027154
 protein coding gene Chr3:78742044-78796405 (-)
FVB/NJ MGP_FVBNJ_G0027122
 protein coding gene Chr3:77030597-77083738 (-)
LP/J MGP_LPJ_G0027262
 protein coding gene Chr3:82892274-82947478 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027141
 protein coding gene Chr3:94222086-94278188 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027803
 protein coding gene Chr3:80852533-80905618 (-)
PWK/PhJ MGP_PWKPhJ_G0026224
 protein coding gene Chr3:78472274-78528617 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026040
 protein coding gene Chr3:80068504-80122597 (-)
WSB/EiJ MGP_WSBEiJ_G0026568
 protein coding gene Chr3:81200531-81255978 (-)



Homology
more
  • Human Ortholog
    GUCY1A1, guanylate cyclase 1 soluble subunit alpha 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GUCY1A1, guanylate cyclase 1 soluble subunit alpha 1
  • Synonyms
    GC-SA3, GC-S-alpha-1, GCS-alpha-3, GUC1A3, GUCA3, GUCSA3, GUCY1A3, MYMY6
  • Links
    NCBI Gene ID: 2982
    neXtProt AC: NX_Q02108
    UniProt: Q02108

  • Chr Location
    4q32.1; chr4:155666726-155737059 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gucy1a1 mouse models; 1 with human GUCY1A1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 4 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display mild elevation of systolic blood pressure, and abnormal blood vessel and platelet responses to NO.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1274
  • Tissues
    222
  • cDNA Data
    12
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033910 Ensembl Gene Model | MGI Sequence Detail 53363 C57BL/6J ±  kb
    transcript ENSMUST00000193924 Ensembl | MGI Sequence Detail 4710 Not Applicable  
    polypeptide ENSMUSP00000142138 Ensembl | MGI Sequence Detail 691 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008349 guanylate cyclase soluble subunit alpha-1
      (term hierarchy)
    • EC
      4.6.1.2
    • InterPro Domains
      IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
      IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved site
      IPR011645 Haem NO binding associated
      IPR042463 Haem NO binding associated domain superfamily
      IPR038158 H-NOX domain superfamily
      IPR024096 NO signalling/Golgi transport ligand-binding domain superfamily
      IPR029787 Nucleotide cyclase
    • GlyGen
      Q9ERL9 2 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 1
      cDNA 15
      Primer pair 2
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1921380, MGI:5927631
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 12
      Diseases 2
      Gene Ontology 9
      Phenotypes 36
    • Earliest
      J:64709 Sharina IG, et al., Genomic organization of alpha 1 and beta 1 subunits of the mammalian soluble guanylyl cyclase genes. Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10878-83
    • Latest
      J:353672 Menges L, et al., It takes two to tango: cardiac fibroblast-derived NO-induced cGMP enters cardiac myocytes and increases cAMP by inhibiting PDE3. Commun Biol. 2023 May 10;6(1):504
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory