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Trp53inp1 Gene Detail
Summary
  • Symbol
    Trp53inp1
  • Name
    transformation related protein 53 inducible nuclear protein 1
  • Synonyms
    2700057G22Rik, SIP, SIP18, SIP27, Stinp, Teap, Tp53inp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926609
    NCBI Gene: 60599
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:11156441-11174379 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 5.03 cM, cytoband A1-A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    372 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926609
 protein coding gene Chr4:11156431-11174379 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028048
 protein coding gene Chr4:7802928-7821974 (+)
A/J MGP_AJ_G0028005
 protein coding gene Chr4:7673672-7691669 (+)
AKR/J MGP_AKRJ_G0027971
 protein coding gene Chr4:7769520-7787981 (+)
BALB/cJ MGP_BALBcJ_G0028017
 protein coding gene Chr4:7594941-7615604 (+)
C3H/HeJ MGP_C3HHeJ_G0027747
 protein coding gene Chr4:7921624-7939545 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028460
 protein coding gene Chr4:8217830-8235843 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025804
 protein coding gene Chr4:7199228-7216921 (+)
CAST/EiJ MGP_CASTEiJ_G0027201
 protein coding gene Chr4:7745278-7763301 (+)
CBA/J MGP_CBAJ_G0027722
 protein coding gene Chr4:8409322-8427242 (+)
DBA/2J MGP_DBA2J_G0027863
 protein coding gene Chr4:7558879-7576692 (+)
FVB/NJ MGP_FVBNJ_G0027829
 protein coding gene Chr4:7394120-7411962 (+)
LP/J MGP_LPJ_G0027973
 protein coding gene Chr4:7883218-7903426 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027862
 protein coding gene Chr4:8616062-8636938 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028519
 protein coding gene Chr4:7769541-7787433 (+)
PWK/PhJ MGP_PWKPhJ_G0026922
 protein coding gene Chr4:7554894-7574842 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026752
 protein coding gene Chr4:7689994-7708682 (+)
WSB/EiJ MGP_WSBEiJ_G0027280
 protein coding gene Chr4:7834712-7853427 (+)



Homology
more
  • Human Ortholog
    TP53INP1, tumor protein p53 inducible nuclear protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TP53INP1, tumor protein p53 inducible nuclear protein 1
  • Synonyms
    p53DINP1, SIP, Teap, TP53DINP1, TP53INP1A, TP53INP1B
  • Links
    NCBI Gene ID: 94241
    neXtProt AC: NX_Q96A56
    UniProt: Q96A56

  • Chr Location
    8q22.1; chr8:94925972-94949378 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Trp53inp1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased plasma and colon oxidative stress, and show increased susceptibility to experimental induction of colorectal tumorigenesis and acute colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    859
  • Tissues
    138
  • cDNA Data
    11
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 60599 NCBI Gene Model | MGI Sequence Detail 17939 C57BL/6J ±  kb
    transcript NM_001199105 RefSeq | MGI Sequence Detail 5432 C57BL/6  
    polypeptide Q9QXE4 UniProt | EBI | MGI Sequence Detail 239 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 1
      cDNA 11
      Primer pair 5
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1919826
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 14
      Diseases 1
      Gene Ontology 11
      Phenotypes 18
    • Earliest
      J:62615 Carrier A, et al., Differential gene expression in CD3epsilon- and RAG1-deficient thymuses: definition of a set of genes potentially involved in thymocyte maturation. Immunogenetics. 1999 Dec;50(5-6):255-70
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory