Fn3k MGI Mouse Gene Detail - MGI:1926834

Symbol

Fn3k
Name

fructosamine 3 kinase
Synonyms

2310074G21Rik

Feature Type

protein coding gene
IDs

MGI:1926834
NCBI Gene: 63828
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr11:121325779-121341316 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 85.38 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

499 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926834	protein coding gene	Chr11:121325739-121341317 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019549	protein coding gene	Chr11:125983134-125998763 (+)
A/J	MGP_AJ_G0019516	protein coding gene	Chr11:120341522-120357088 (+)
AKR/J	MGP_AKRJ_G0019486	protein coding gene	Chr11:123995386-124010960 (+)
BALB/cJ	MGP_BALBcJ_G0019491	protein coding gene	Chr11:120721157-120736727 (+)
C3H/HeJ	MGP_C3HHeJ_G0019297	protein coding gene	Chr11:124327112-124342681 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019940	protein coding gene	Chr11:129798295-129813845 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017565	protein coding gene	Chr11:117330597-117346538 (+)
CAST/EiJ	MGP_CASTEiJ_G0018851	protein coding gene	Chr11:125812534-125829760 (+)
CBA/J	MGP_CBAJ_G0019268	protein coding gene	Chr11:134830252-134847946 (+)
DBA/2J	MGP_DBA2J_G0019381	protein coding gene	Chr11:119729140-119745210 (+)
FVB/NJ	MGP_FVBNJ_G0019372	protein coding gene	Chr11:119450832-119466687 (+)
LP/J	MGP_LPJ_G0019452	protein coding gene	Chr11:126255174-126272774 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019405	protein coding gene	Chr11:133638482-133654041 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019979	protein coding gene	Chr11:124686384-124701961 (+)
PWK/PhJ	MGP_PWKPhJ_G0018618	protein coding gene	Chr11:121158684-121175555 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018408	protein coding gene	Chr11:124367471-124445674 (+)
WSB/EiJ	MGP_WSBEiJ_G0018904	protein coding gene	Chr11:124648768-124664257 (+)

Human Ortholog

FN3K, fructosamine 3 kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FN3K, fructosamine 3 kinase
Links

HGNC:24822

NCBI Gene ID: 64122

neXtProt AC: NX_Q9H479

UniProt: Q9H479
Chr Location

17q25.3; chr17:82735615-82751196 (+) GRCh38

MGI Vertebrate Homology

Fn3k stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FN3K
Protein SuperFamily

Ketosamine-3-kinase
Gene Tree

Fn3k

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Targeted

3
Incidental Mutations

CvDC
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele grow and reproduce normally and appear healthy while cellular levels of glycated proteins and free fructoselysine are elevated in several tissues.

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All GO Annotations

16
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

19
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fn3k

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All Sequences

46
RefSeq

4
UniProt

3
CCDS

CCDS25776.1, CCDS25777.1

Ensembl

ENSMUSG00000025175 (Evidence)
NCBI Gene

63828

			Length	Strain/Species	Flank
genomic	63828	NCBI Gene Model \| MGI Sequence Detail	15538	C57BL/6J	± kb
transcript	NM_001038699	RefSeq \| MGI Sequence Detail	3882	C57BL/6
polypeptide	Q9ER35	UniProt \| EBI \| MGI Sequence Detail	309	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007582 fructosamine-3-kinase

(term hierarchy)
EC

2.7.1.171, 2.7.1.172
InterPro Domains

IPR016477 Fructosamine/Ketosamine-3-kinase

IPR011009 Protein kinase-like domain superfamily

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All nucleic 20

cDNA 20

Microarray probesets 6

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MGI:1916917

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 10

Phenotypes 5
Earliest

J:64795 Delpierre G, et al., Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase. Diabetes. 2000 Oct;49(10):1627-34
Latest

J:353480 Huang S, et al., Mutations in linker-2 of KLF1 impair expression of membrane transporters and cytoskeletal proteins causing hemolysis. Nat Commun. 2024 Aug 15;15(1):7019

TSS for Fn3k:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106404	Chr11:121325774-121325813 (+)	15 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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