Bco1 MGI Mouse Gene Detail - MGI:1926923 - beta-carotene oxygenase 1

Symbol

Bco1
Name

beta-carotene oxygenase 1
Synonyms

Bcdo, Bcdo1, Bcmo1, beta-CD, betaCMOOX, Cmoi

Feature Type

protein coding gene
IDs

MGI:1926923
NCBI Gene: 63857
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr8:117822593-117860459 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 63.61 cM, cytoband E1
Mapping Data

1 experiment

SNPs within 2kb

1281 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926923	protein coding gene	Chr8:117822590-117860459 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034171	protein coding gene	Chr8:120227387-120270084 (+)
A/J	MGP_AJ_G0034151	protein coding gene	Chr8:115335409-115375185 (+)
AKR/J	MGP_AKRJ_G0034078	protein coding gene	Chr8:118692678-118732192 (+)
BALB/cJ	MGP_BALBcJ_G0034145	protein coding gene	Chr8:115533406-115571874 (+)
C3H/HeJ	MGP_C3HHeJ_G0033856	protein coding gene	Chr8:119418238-119459220 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034665	protein coding gene	Chr8:124315633-124355565 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031607	protein coding gene	Chr8:108261813-108298717 (+)
CAST/EiJ	MGP_CASTEiJ_G0033183	protein coding gene	Chr8:119243772-119289822 (+)
CBA/J	MGP_CBAJ_G0033829	protein coding gene	Chr8:128788278-128835522 (+)
DBA/2J	MGP_DBA2J_G0033985	protein coding gene	Chr8:114561049-114598877 (+)
FVB/NJ	MGP_FVBNJ_G0033928	protein coding gene	Chr8:113550825-113595035 (+)
LP/J	MGP_LPJ_G0034074	protein coding gene	Chr8:120358511-120399103 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033975	protein coding gene	Chr8:131395362-131439110 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034683	protein coding gene	Chr8:118778450-118818431 (+)
PWK/PhJ	MGP_PWKPhJ_G0032885	protein coding gene	Chr8:114263914-114304594 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032725	protein coding gene	Chr8:117476847-117516544 (+)
WSB/EiJ	MGP_WSBEiJ_G0033299	protein coding gene	Chr8:119491465-119538933 (+)

Human Ortholog

BCO1, beta-carotene oxygenase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BCO1, beta-carotene oxygenase 1
Synonyms

BCDO, BCDO1, BCMO, BCMO1, BCO
Links

HGNC:13815

NCBI Gene ID: 53630

neXtProt AC: NX_Q9HAY6

UniProt: Q9HAY6
Chr Location

16q23.2; chr16:81238689-81291142 (+) GRCh38

MGI Vertebrate Homology

Bco1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: BCO1
Gene Tree

Bco1

less

Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

1
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display fatty livers, elevated serum free fatty acid levels, increased susceptibility to diet-induced obesity, and impaired conversion of beta-carotene to vitamin A.

less

All GO Annotations

22
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

898
Tissues

135
cDNA Data

16
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bco1

ZFIN bco1

less

All Sequences

43
RefSeq

6
UniProt

3
CCDS

CCDS22697.1, CCDS52679.1

Ensembl

ENSMUSG00000031845 (Evidence)
NCBI Gene

63857

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031845	Ensembl Gene Model \| MGI Sequence Detail	37867	C57BL/6J	± kb
transcript	ENSMUST00000034308	Ensembl \| MGI Sequence Detail	2338	Not Applicable
polypeptide	ENSMUSP00000034308	Ensembl \| MGI Sequence Detail	566	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000004707 beta,beta-carotene 15,15'-dioxygenase

(term hierarchy)
EC

1.13.11.63
InterPro Domains

IPR004294 Carotenoid oxygenase

less

All nucleic 22

cDNA 16

Primer pair 5

Other 1

Microarray probesets 2

Summaries

All 68

Developmental Gene Expression 9

Gene Ontology 11

Phenotypes 31
Earliest

J:66309 Wyss A, et al., Cloning and expression of beta,beta-carotene 15,15'-dioxygenase. Biochem Biophys Res Commun. 2000 May 10;271(2):334-6
Latest

J:342035 Miller AP, et al., Bioavailability and provitamin A activity of neurosporaxanthin in mice. Commun Biol. 2023 Oct 20;6(1):1068

TSS for Bco1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79578	Chr8:117822598-117822614 (+)	13 bp
Tssr79579	Chr8:117842579-117842583 (+)	19,988 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24