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Net1 Gene Detail
Summary
  • Symbol
    Net1
  • Name
    neuroepithelial cell transforming gene 1
  • Synonyms
    0610025H04Rik, 9530071N24Rik, mNET1, Net1 homolog
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927138
    NCBI Gene: 56349
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:3932018-3968220 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 2.17 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1058 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927138
 protein coding gene Chr13:3932018-3968220 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020199
 protein coding gene Chr13:372882-407333 (-)
A/J MGP_AJ_G0020155
 protein coding gene Chr13:472188-506544 (-)
AKR/J MGP_AKRJ_G0020130
 protein coding gene Chr13:479633-516065 (-)
BALB/cJ MGP_BALBcJ_G0020138
 protein coding gene Chr13:472645-507283 (-)
C3H/HeJ MGP_C3HHeJ_G0019942
 protein coding gene Chr13:542844-581162 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020585
 protein coding gene Chr13:432189-481533 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018197
 protein coding gene Chr13:391736-425226 (-)
CAST/EiJ MGP_CASTEiJ_G0019482
 protein coding gene Chr13:374871-416399 (-)
CBA/J MGP_CBAJ_G0019909
 protein coding gene Chr13:441082-477881 (-)
DBA/2J MGP_DBA2J_G0020026
 protein coding gene Chr13:388049-422396 (-)
FVB/NJ MGP_FVBNJ_G0020011
 protein coding gene Chr13:369626-407266 (-)
LP/J MGP_LPJ_G0020100
 protein coding gene Chr13:443061-483649 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020047
 protein coding gene Chr13:482626-522033 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020613
 protein coding gene Chr13:459621-498124 (-)
PWK/PhJ MGP_PWKPhJ_G0019244
 protein coding gene Chr13:452724-489659 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019049
 protein coding gene Chr13:476519-514615 (-)
WSB/EiJ MGP_WSBEiJ_G0019540
 protein coding gene Chr13:384649-422010 (-)



Homology
more
  • Human Ortholog
    NET1, neuroepithelial cell transforming 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NET1, neuroepithelial cell transforming 1
  • Synonyms
    ARHGEF8, NET1A
  • Links
    NCBI Gene ID: 10276
    neXtProt AC: NX_Q7Z628
    UniProt: Q7Z628

  • Chr Location
    10p15.1; chr10:5412557-5459056 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit delayed mammary gland development during puberty associated with slower ductal extension, reduced ductal branching and epithelial cell proliferation, disorganized myoepithelial and ductal epithelial cells, and increased collagen deposition.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    2
  • cDNA Data
    77
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56349 NCBI Gene Model | MGI Sequence Detail 36203 C57BL/6J ±  kb
    transcript NM_019671 RefSeq | MGI Sequence Detail 3995 C57BL/6  
    polypeptide Q9Z206 UniProt | EBI | MGI Sequence Detail 595 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 81
      cDNA 79
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1915052, MGI:1925813, MGI:2145270, MGI:2145334
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 7
    • Earliest
      J:46957 Alberts AS, et al., Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7. J Biol Chem. 1998 Apr 10;273(15):8616-22
    • Latest
      J:344117 Wang S, et al., Microtubule-dependent apical polarization of basement membrane matrix mRNAs in mouse epithelial cells. Cells Dev. 2023 Dec 14;177:203898
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory