Git1 MGI Mouse Gene Detail - MGI:1927140

Symbol

Git1
Name

GIT ArfGAP 1
Synonyms

Cat-1, p95Cat

Feature Type

protein coding gene
IDs

MGI:1927140
NCBI Gene: 216963
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr11:77384388-77398612 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 46.61 cM
Mapping Data

1 experiment

SNPs within 2kb

252 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927140	protein coding gene	Chr11:77384114-77398612 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018748	protein coding gene	Chr11:78400278-78416702 (+)
A/J	MGP_AJ_G0018714	protein coding gene	Chr11:75439276-75453969 (+)
AKR/J	MGP_AKRJ_G0018684	protein coding gene	Chr11:77727931-77742541 (+)
BALB/cJ	MGP_BALBcJ_G0018688	protein coding gene	Chr11:75823882-75838704 (+)
C3H/HeJ	MGP_C3HHeJ_G0018501	protein coding gene	Chr11:77752849-77767020 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019139	protein coding gene	Chr11:80859646-80877776 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016774	protein coding gene	Chr11:72421816-72435617 (+)
CAST/EiJ	MGP_CASTEiJ_G0018055	protein coding gene	Chr11:78147014-78163467 (+)
CBA/J	MGP_CBAJ_G0018471	protein coding gene	Chr11:84371765-84393602 (+)
DBA/2J	MGP_DBA2J_G0018580	protein coding gene	Chr11:75025517-75039687 (+)
FVB/NJ	MGP_FVBNJ_G0018570	protein coding gene	Chr11:74596994-74609726 (+)
LP/J	MGP_LPJ_G0018651	protein coding gene	Chr11:78962860-78977068 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018596	protein coding gene	Chr11:84833161-84847302 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019179	protein coding gene	Chr11:77939049-77953209 (+)
PWK/PhJ	MGP_PWKPhJ_G0017826	protein coding gene	Chr11:75782685-75797405 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017617	protein coding gene	Chr11:77551705-77566726 (+)
WSB/EiJ	MGP_WSBEiJ_G0018108	protein coding gene	Chr11:77757980-77774707 (+)

Human Ortholog

GIT1, GIT ArfGAP 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GIT1, GIT ArfGAP 1
Synonyms

p95-APP1
Links

HGNC:4272

NCBI Gene ID: 28964

neXtProt AC: NX_Q9Y2X7

UniProt: Q9Y2X7
Chr Location

17q11.2; chr17:29573475-29594054 (-) GRCh38

MGI Vertebrate Homology

Git1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GIT1
Gene Tree

Git1

Diseases

1 with Git1 mouse models; 1 with human GIT1 associations

Human Disease

Mouse Models

attention deficit hyperactivity disorder

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

30 phenotypes from 3 alleles in 4 genetic backgrounds
36 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

17
Targeted

6
Genomic Mutations

2 involving Git1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit postnatal lethality associated with abnormal lung vascular development with surviving mice exhibiting abnormal learning and anxiety related behavior.

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All GO Annotations

77
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

1
cDNA Data

112
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase git1

ZFIN git1

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All Sequences

42
RefSeq

4
UniProt

3
CCDS

CCDS25080.1, CCDS88196.1

Ensembl

ENSMUSG00000011877 (Evidence)
NCBI Gene

216963

			Length	Strain/Species	Flank
genomic	ENSMUSG00000011877	Ensembl Gene Model \| MGI Sequence Detail	14225	C57BL/6J	± kb
transcript	ENSMUST00000037285	Ensembl \| MGI Sequence Detail	3512	Not Applicable
polypeptide	ENSMUSP00000037210	Ensembl \| MGI Sequence Detail	770	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007989 ARF GTPase-activating protein GIT1

(term hierarchy)
PDB

6JMU
InterPro Domains

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

IPR038508 ArfGAP domain superfamily

IPR037278 ARFGAP/RecO-like zinc finger

IPR001164 Arf GTPase activating protein

IPR032352 Arf GTPase-activating protein GIT1/2, coiled-coil domain

IPR022018 ARF GTPase-activating protein GIT1, C-terminal

IPR047161 ARF GTPase-activating protein Git-like

IPR013724 GIT, Spa2 homology (SHD) domain
GlyGen

Q68FF6 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 112

cDNA 112

Microarray probesets 3

Summaries

All 77

Developmental Gene Expression 5

Diseases 1

Gene Ontology 16

Phenotypes 36
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:346347 Xu T, et al., Git1-PGK1 interaction achieves self-protection against spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling. Redox Biol. 2023 Mar 20;62:102682

TSS for Git1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103144	Chr11:77384020-77384039 (+)	-358 bp
Tssr103145	Chr11:77384091-77384128 (+)	-278 bp
Tssr103146	Chr11:77384137-77384161 (+)	-239 bp
Tssr103147	Chr11:77384194-77384220 (+)	-181 bp
Tssr103148	Chr11:77384234-77384313 (+)	-114 bp
Tssr103149	Chr11:77387159-77387166 (+)	2,775 bp
Tssr103150	Chr11:77389010-77389016 (+)	4,625 bp
Tssr103151	Chr11:77391713-77391753 (+)	7,345 bp
Tssr103152	Chr11:77394626-77394661 (+)	10,256 bp
Tssr103153	Chr11:77394682-77394695 (+)	10,301 bp
Tssr103154	Chr11:77394702-77394712 (+)	10,319 bp
Tssr103155	Chr11:77396374-77396385 (+)	11,992 bp
Tssr103156	Chr11:77397748-77397778 (+)	13,375 bp
Tssr103157	Chr11:77397984-77397997 (+)	13,603 bp
Tssr103158	Chr11:77398136-77398158 (+)	13,759 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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