Chst11 MGI Mouse Gene Detail - MGI:1927166 - carbohydrate sulfotransferase 11

Symbol

Chst11
Name

carbohydrate sulfotransferase 11
Synonyms

1110020P09Rik, C4ST, C4ST-1, C4ST1, chondroitin 4

Feature Type

protein coding gene
IDs

MGI:1927166
NCBI Gene: 58250
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr10:82821332-83031734 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 40.66 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

5557 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927166	protein coding gene	Chr10:82820274-83031738 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017583	protein coding gene	Chr10:83756848-83977760 (+)
A/J	MGP_AJ_G0017563	protein coding gene	Chr10:80924304-81136137 (+)
AKR/J	MGP_AKRJ_G0017522	protein coding gene	Chr10:83178193-83392607 (+)
BALB/cJ	MGP_BALBcJ_G0017526	protein coding gene	Chr10:81195505-81411192 (+)
C3H/HeJ	MGP_C3HHeJ_G0017348	protein coding gene	Chr10:83251691-83474966 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017983	protein coding gene	Chr10:86675681-86907076 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015667	protein coding gene	Chr10:76656903-76870411 (+)
CAST/EiJ	MGP_CASTEiJ_G0016915	protein coding gene	Chr10:83165996-83406284 (+)
CBA/J	MGP_CBAJ_G0017318	protein coding gene	Chr10:90248999-90487157 (+)
DBA/2J	MGP_DBA2J_G0017424	protein coding gene	Chr10:80095113-80305994 (+)
FVB/NJ	MGP_FVBNJ_G0017418	protein coding gene	Chr10:79327535-79545230 (+)
LP/J	MGP_LPJ_G0017496	protein coding gene	Chr10:84402229-84618076 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017446	protein coding gene	Chr10:91913132-92130239 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018020	protein coding gene	Chr10:83115654-83333165 (+)
PWK/PhJ	MGP_PWKPhJ_G0016696	protein coding gene	Chr10:79975502-80190063 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016486	protein coding gene	Chr10:81801773-82013579 (+)
WSB/EiJ	MGP_WSBEiJ_G0016974	protein coding gene	Chr10:83141807-83363307 (+)

Human Ortholog

CHST11, carbohydrate sulfotransferase 11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CHST11, carbohydrate sulfotransferase 11
Synonyms

C4ST, C4ST-1, C4ST1, HSA269537, OCBMD
Links

HGNC:17422

NCBI Gene ID: 50515

neXtProt AC: NX_Q9NPF2

UniProt: Q9NPF2
Chr Location

12q23.3; chr12:104455295-104762014 (+) GRCh38

MGI Vertebrate Homology

Chst11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CHST11
Gene Tree

Chst11

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Phenotype Summary

43 phenotypes from 3 alleles in 3 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

3
Genomic Mutations

1 involving Chst11
Incidental Mutations

APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit neonatal lethality associated with respiratory distress, dwarfism, and abnormal skeletal structures.

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All GO Annotations

32
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

835
Tissues

122
cDNA Data

7
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase chst11

ZFIN chst11

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All Sequences

41
RefSeq

6
UniProt

3
CCDS

CCDS24074.1

Ensembl

ENSMUSG00000034612 (Evidence)
NCBI Gene

58250

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034612	Ensembl Gene Model \| MGI Sequence Detail	210403	C57BL/6J	± kb
transcript	ENSMUST00000040110	Ensembl \| MGI Sequence Detail	5527	Not Applicable
polypeptide	ENSMUSP00000045349	Ensembl \| MGI Sequence Detail	352	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005471 carbohydrate sulfotransferase 11

(term hierarchy)
EC

2.8.2.-, 2.8.2.5
InterPro Domains

IPR018011 Carbohydrate sulfotransferase 8-10

IPR005331 Sulfotransferase
GlyGen

Q9JME2 4 sites, 2 N-linked glycans (2 sites)

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All nucleic 10

cDNA 7

Primer pair 2

Other 1

Microarray probesets 4

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MGI:1915897

Summaries

All 59

Developmental Gene Expression 10

Gene Ontology 11

Phenotypes 18
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Chst11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94864	Chr10:82821179-82821215 (+)	-135 bp
Tssr94865	Chr10:82821218-82821270 (+)	-88 bp
Tssr94866	Chr10:82821277-82821288 (+)	-49 bp
Tssr94867	Chr10:82821307-82821338 (+)	-9 bp
Tssr94868	Chr10:82823044-82823045 (+)	1,713 bp
Tssr94869	Chr10:82930461-82930462 (+)	109,130 bp
Tssr94870	Chr10:82933921-82933924 (+)	112,591 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24