B4galt5 MGI Mouse Gene Detail - MGI:1927169 - UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5

Symbol

B4galt5
Name

UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5
Synonyms

9430078I07Rik

Feature Type

protein coding gene
IDs

MGI:1927169
NCBI Gene: 56336
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr2:167140364-167191103 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 87.22 cM, cytoband H3
Mapping Data

3 experiments

SNPs within 2kb

1186 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927169	protein coding gene	Chr2:167140364-167191155 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026911	protein coding gene	Chr2:173018188-173070878 (-)
A/J	MGP_AJ_G0026878	protein coding gene	Chr2:165902310-165954028 (-)
AKR/J	MGP_AKRJ_G0026849	protein coding gene	Chr2:170847845-170900447 (-)
BALB/cJ	MGP_BALBcJ_G0026887	protein coding gene	Chr2:166253749-166304758 (-)
C3H/HeJ	MGP_C3HHeJ_G0026629	protein coding gene	Chr2:171215706-171267351 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027334	protein coding gene	Chr2:178056840-178112303 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024705	protein coding gene	Chr2:159226499-159277214 (-)
CAST/EiJ	MGP_CASTEiJ_G0026087	protein coding gene	Chr2:171679315-171732665 (-)
CBA/J	MGP_CBAJ_G0026606	protein coding gene	Chr2:184577896-184636996 (-)
DBA/2J	MGP_DBA2J_G0026744	protein coding gene	Chr2:165021957-165072756 (-)
FVB/NJ	MGP_FVBNJ_G0026710	protein coding gene	Chr2:163532461-163583565 (-)
LP/J	MGP_LPJ_G0026845	protein coding gene	Chr2:173037154-173093942 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026729	protein coding gene	Chr2:187983626-188034954 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027391	protein coding gene	Chr2:170768345-170823878 (-)
PWK/PhJ	MGP_PWKPhJ_G0025824	protein coding gene	Chr2:164674446-164727092 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025625	protein coding gene	Chr2:169698769-169751052 (-)
WSB/EiJ	MGP_WSBEiJ_G0026160	protein coding gene	Chr2:171687239-171738053 (-)

Human Ortholog

B4GALT5, beta-1,4-galactosyltransferase 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

B4GALT5, beta-1,4-galactosyltransferase 5
Synonyms

B4Gal-T5, beta4Gal-T5, BETA4-GALT-IV, beta4GalT-V, gt-V
Links

HGNC:928

NCBI Gene ID: 9334

neXtProt AC: NX_O43286

UniProt: O43286
Chr Location

20q13.13; chr20:49632945-49713878 (-) GRCh38

MGI Vertebrate Homology

B4galt5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: B4GALT5
Gene Tree

B4galt5

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

2
Gene trapped

8
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in lethality before weaning. Heterozygous mutant mice exhibit increased anxiety-like response.

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All GO Annotations

19
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

891
Tissues

130
cDNA Data

12
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase b4galt5

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All Sequences

54
RefSeq

4
UniProt

4
CCDS

CCDS17098.1

Ensembl

ENSMUSG00000017929 (Evidence)
NCBI Gene

56336

			Length	Strain/Species	Flank
genomic	ENSMUSG00000017929	Ensembl Gene Model \| MGI Sequence Detail	50740	C57BL/6J	± kb
transcript	ENSMUST00000109221	Ensembl \| MGI Sequence Detail	4210	Not Applicable
polypeptide	ENSMUSP00000104844	Ensembl \| MGI Sequence Detail	388	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000004609 beta-1,4-galactosyltransferase 5

(term hierarchy)
EC

2.4.1.-, 2.4.1.274
InterPro Domains

IPR003859 Beta-1,4-galactosyltransferase

IPR027791 Galactosyltransferase, C-terminal

IPR027995 Galactosyltransferase, N-terminal

IPR029044 Nucleotide-diphospho-sugar transferases
GlyGen

Q9JMK0 7 sites, 1 N-linked glycan (2 sites)

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All nucleic 13

cDNA 12

Primer pair 1

Microarray probesets 5

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MGI:1924610, MGI:2139281, MGI:2139367

Summaries

All 53

Developmental Gene Expression 3

Gene Ontology 13

Phenotypes 17
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for B4galt5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr27770	Chr2:167191263-167191291 (-)	-174 bp
Tssr27769	Chr2:167191087-167191169 (-)	-25 bp
Tssr767	Chr2:167191078-167191083 (-)	22 bp
Tssr27768	Chr2:167191062-167191077 (-)	33 bp
Tssr27767	Chr2:167191031-167191042 (-)	66 bp
Tssr27766	Chr2:167181306-167181312 (-)	9,794 bp
Tssr27765	Chr2:167155086-167155098 (-)	36,011 bp
Tssr27764	Chr2:167151216-167151226 (-)	39,882 bp
Tssr27763	Chr2:167144131-167144141 (-)	46,967 bp
Tssr27762	Chr2:167143398-167143407 (-)	47,700 bp
Tssr27761	Chr2:167142823-167142837 (-)	48,273 bp
Tssr27760	Chr2:167142695-167142699 (-)	48,406 bp
Tssr27759	Chr2:167141637-167141654 (-)	49,457 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24