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Suclg1 Gene Detail
Summary
  • Symbol
    Suclg1
  • Name
    succinate-CoA ligase, GDP-forming, alpha subunit
  • Synonyms
    1500000I01Rik, Sucla1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927234
    NCBI Gene: 56451
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:73225488-73253890 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 32.40 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    900 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927234
 protein coding gene Chr6:73225365-73253894 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030887
 protein coding gene Chr6:73869966-73901734 (+)
A/J MGP_AJ_G0030857
 protein coding gene Chr6:70943543-70976324 (+)
AKR/J MGP_AKRJ_G0030786
 protein coding gene Chr6:73073257-73102277 (+)
BALB/cJ MGP_BALBcJ_G0030868
 protein coding gene Chr6:71008787-71037692 (+)
C3H/HeJ MGP_C3HHeJ_G0030844
 protein coding gene Chr6:111144717-111177718 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031326
 protein coding gene Chr6:75762164-75790516 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028515
 protein coding gene Chr6:70121986-70150210 (+)
CAST/EiJ MGP_CASTEiJ_G0029976
 protein coding gene Chr6:72966127-72994576 (+)
CBA/J MGP_CBAJ_G0030555
 protein coding gene Chr6:78890739-78924025 (+)
DBA/2J MGP_DBA2J_G0030707
 protein coding gene Chr6:70354927-70384901 (+)
FVB/NJ MGP_FVBNJ_G0030660
 protein coding gene Chr6:69757041-69786596 (+)
LP/J MGP_LPJ_G0030786
 protein coding gene Chr6:73765734-73797354 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030695
 protein coding gene Chr6:82225243-82255140 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031352
 protein coding gene Chr6:72916338-72946135 (+)
PWK/PhJ MGP_PWKPhJ_G0029692
 protein coding gene Chr6:69300582-69329254 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029520
 protein coding gene Chr6:71679212-71707452 (+)
WSB/EiJ MGP_WSBEiJ_G0030058
 protein coding gene Chr6:73293026-73325280 (+)



Homology
more
  • Human Ortholog
    SUCLG1, succinate-CoA ligase GDP/ADP-forming subunit alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SUCLG1, succinate-CoA ligase GDP/ADP-forming subunit alpha
  • Synonyms
    GALPHA, MTDPS9, SUCLA1
  • Links
    NCBI Gene ID: 8802
    neXtProt AC: NX_P53597
    UniProt: P53597

  • Chr Location
    2p11.2; chr2:84423528-84460045 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SUCLG1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    24
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    852
  • Tissues
    107
  • cDNA Data
    203
  • Literature Summary
    9
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56451 NCBI Gene Model | MGI Sequence Detail 28403 C57BL/6J ±  kb
transcript NM_019879 RefSeq | MGI Sequence Detail 1407 C57BL/6  
polypeptide Q9WUM5 UniProt | EBI | MGI Sequence Detail 346 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000015812 succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
    (term hierarchy)
  • EC
    6.2.1.4, 6.2.1.5
  • InterPro Domains
    IPR017440 ATP-citrate lyase/succinyl-CoA ligase, active site
    IPR033847 ATP-citrate lyase/succinyl-CoA ligase, conserved site
    IPR005811 ATP-citrate synthase/succinyl-CoA ligase, C-terminal domain
    IPR003781 CoA-binding
    IPR036291 NAD(P)-binding domain superfamily
    IPR005810 Succinyl-CoA ligase, alpha subunit
    IPR016102 Succinyl-CoA synthetase-like
  • GlyGen
    Q9WUM5 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 207
    cDNA 204
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGI:1915249
References
more
  • Summaries
    All 55
    Developmental Gene Expression 9
    Gene Ontology 11
    Phenotypes 15
  • Earliest
    J:50333 Johnson JD, et al., Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes. J Biol Chem. 1998 Oct 16;273(42):27580-6
  • Latest
    J:348785 Zhang D, et al., Maternal Ezh1/2 deficiency impairs the function of mitochondria in mouse oocytes and early embryos. J Cell Physiol. 2024 Mar 26;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory