Rala MGI Mouse Gene Detail - MGI:1927243 - v-ral simian leukemia viral oncogene A (ras related)

Symbol

Rala
Name

v-ral simian leukemia viral oncogene A (ras related)
Synonyms

3010001O15Rik, Ral, Rasl1

Feature Type

protein coding gene
IDs

MGI:1927243
NCBI Gene: 56044
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr13:18055160-18118802 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 6.05 cM, cytoband A3.1
Mapping Data

11 experiments

SNPs within 2kb

1402 from dbSNP Build 142
Strain Annotations

18
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927243	protein coding gene	Chr13:18055156-18118824 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020253	protein coding gene	Chr13:14946112-15008264 (-)
A/J	MGP_AJ_G0020210	protein coding gene	Chr13:14763426-14814265 (-)
AKR/J	MGP_AKRJ_G0020184	protein coding gene	Chr13:14956736-15011153 (-)
BALB/cJ	MGP_BALBcJ_G0020196	protein coding gene	Chr13:14734957-14786513 (-)
C3H/HeJ	MGP_C3HHeJ_G0020000	protein coding gene	Chr13:15076038-15130217 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020640	protein coding gene	Chr13:15669453-15726288 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018247	protein coding gene	Chr13:13279676-13330077 (-)
CAST/EiJ	MGP_CASTEiJ_G0019534	protein coding gene	Chr13:14775652-14832071 (-)
CBA/J	MGP_CBAJ_G0019964	protein coding gene	Chr13:16153036-16216432 (-)
DBA/2J	MGP_DBA2J_G0020083	protein coding gene	Chr13:14378049-14428889 (-)
FVB/NJ	MGP_FVBNJ_G0020064	protein coding gene	Chr13:14078834-14129959 (-)
LP/J	MGP_LPJ_G0020153	protein coding gene	Chr13:15235355-15288934 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020102	protein coding gene	Chr13:16519449-16578301 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020668	protein coding gene	Chr13:14771176-14832775 (-)
PWK/PhJ	MGP_PWKPhJ_G0019297	protein coding gene	Chr13:14424911-14476797 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019103	protein coding gene	Chr13:13907238-13959913 (-)
WSB/EiJ	MGP_WSBEiJ_G0019594	protein coding gene	Chr13:14791399-14847014 (-)

Human Ortholog

RALA, RAS like proto-oncogene A

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RALA, RAS like proto-oncogene A
Synonyms

HINCONS, RAL
Links

HGNC:9839

NCBI Gene ID: 5898

neXtProt AC: NX_P11233

UniProt: P11233
Chr Location

7p14.1; chr7:39623565-39708120 (+) GRCh38

MGI Vertebrate Homology

Rala stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RALA
Gene Tree

Rala

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Phenotype Summary

42 phenotypes from 4 alleles in 4 genetic backgrounds
10 phenotypes from multigenic genotypes
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

33
Endonuclease-mediated

1
Gene trapped

25
Radiation induced

1
Targeted

6
Genomic Mutations

1 involving Rala
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit complete preweaning lethality and exencephaly.

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All GO Annotations

67
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

828
Tissues

81
cDNA Data

10
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rala

ZFIN ralaa

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All Sequences

41
RefSeq

2
UniProt

3
CCDS

CCDS26255.1

Ensembl

ENSMUSG00000008859 (Evidence)
NCBI Gene

56044

			Length	Strain/Species	Flank
genomic	56044	NCBI Gene Model \| MGI Sequence Detail	63643	C57BL/6J	± kb
transcript	NM_019491	RefSeq \| MGI Sequence Detail	2662	ZRU/MplStud
polypeptide	P63321	UniProt \| EBI \| MGI Sequence Detail	206	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013695 Ras-related protein Ral-A

(term hierarchy)
EC

3.6.5.2
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001806 Small GTPase

IPR020849 Small GTPase, Ras-type

IPR005225 Small GTP-binding protein domain
GlyGen

P63321 1 site, 1 O-linked glycan (1 site)

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All nucleic 12

cDNA 11

Primer pair 1

Microarray probesets 7

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MGD-MRK-13757, MGD-MRK-13771, MGI:1917666, MGI:2145427, MGI:97861

Summaries

All 80

Developmental Gene Expression 5

Gene Ontology 16

Phenotypes 24
Earliest

J:10344 Justice MJ, et al., A molecular genetic linkage map of mouse chromosome 13 anchored by the beige (bg) and satin (sa) loci. Genomics. 1990 Feb;6(2):341-51
Latest

J:350444 Martinez-Mayer J, et al., Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Genome Med. 2024 May 31;16(1):75

TSS for Rala:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr121540	Chr13:18118736-18118824 (-)	22 bp
Tssr121539	Chr13:18118722-18118727 (-)	77 bp
Tssr121538	Chr13:18114567-18114597 (-)	4,220 bp
Tssr121537	Chr13:18067756-18067774 (-)	51,037 bp
Tssr121536	Chr13:18063158-18063171 (-)	55,637 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24