Pals2 MGI Mouse Gene Detail - MGI:1927340 - protein associated with LIN7 2, MAGUK family member

Symbol

Pals2
Name

protein associated with LIN7 2, MAGUK family member
Synonyms

Mpp6, P55t, Pals2

Feature Type

protein coding gene
IDs

MGI:1927340
NCBI Gene: 56524
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr6:50087221-50175919 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 24.13 cM
Mapping Data

3 experiments

SNPs within 2kb

2157 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927340	protein coding gene	Chr6:50087206-50176134 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030727	protein coding gene	Chr6:49198873-49294424 (+)
A/J	MGP_AJ_G0030698	protein coding gene	Chr6:46907042-46997876 (+)
AKR/J	MGP_AKRJ_G0030623	protein coding gene	Chr6:48560704-48656975 (+)
BALB/cJ	MGP_BALBcJ_G0030708	protein coding gene	Chr6:47250051-47339777 (+)
C3H/HeJ	MGP_C3HHeJ_G0030421	protein coding gene	Chr6:48584354-48674718 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031163	protein coding gene	Chr6:50309074-50407032 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028370	protein coding gene	Chr6:44518308-44605295 (+)
CAST/EiJ	MGP_CASTEiJ_G0029825	protein coding gene	Chr6:48287977-48383247 (+)
CBA/J	MGP_CBAJ_G0030396	protein coding gene	Chr6:52421004-52524690 (+)
DBA/2J	MGP_DBA2J_G0030545	protein coding gene	Chr6:46817575-46908708 (+)
FVB/NJ	MGP_FVBNJ_G0030497	protein coding gene	Chr6:46462536-46548741 (+)
LP/J	MGP_LPJ_G0030630	protein coding gene	Chr6:49160474-49251368 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030531	protein coding gene	Chr6:55141506-55240150 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031192	protein coding gene	Chr6:48473504-48569338 (+)
PWK/PhJ	MGP_PWKPhJ_G0029537	protein coding gene	Chr6:46383318-46479922 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029373	protein coding gene	Chr6:47802888-47893000 (+)
WSB/EiJ	MGP_WSBEiJ_G0029902	protein coding gene	Chr6:48436476-48531485 (+)

Human Ortholog

PALS2, protein associated with LIN7 2, MAGUK p55 family member

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PALS2, protein associated with LIN7 2, MAGUK p55 family member
Synonyms

MPP6, p55T, VAM-1, VAM1
Links

HGNC:18167

NCBI Gene ID: 51678

neXtProt AC: NX_Q9NZW5

UniProt: Q9NZW5
Chr Location

7p15.3; chr7:24573268-24694193 (+) GRCh38

MGI Vertebrate Homology

Pals2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PALS2
Gene Tree

Pals2

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

43
Endonuclease-mediated

4
Gene trapped

36
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

10
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

4
cDNA Data

9
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pals2

ZFIN pals2b

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All Sequences

96
RefSeq

32
UniProt

9
CCDS

CCDS20128.1, CCDS51770.1

Ensembl

ENSMUSG00000038388 (Evidence)
NCBI Gene

56524

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038388	Ensembl Gene Model \| MGI Sequence Detail	88699	C57BL/6J	± kb
transcript	ENSMUST00000166318	Ensembl \| MGI Sequence Detail	2222	Not Applicable
polypeptide	ENSMUSP00000125880	Ensembl \| MGI Sequence Detail	553	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000029634 protein PALS2

(term hierarchy)
InterPro Domains

IPR020590 Guanylate kinase, conserved site

IPR008144 Guanylate kinase-like domain

IPR008145 Guanylate kinase/L-type calcium channel beta subunit

IPR004172 L27 domain

IPR014775 L27 domain, C-terminal

IPR036892 L27 domain superfamily

IPR050716 Membrane-associated guanylate kinase

IPR035603 MPP6, SH3 domain

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily
GlyGen

Q9JLB0 1 site, 1 O-linked glycan (1 site)

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All nucleic 12

Genomic 2

cDNA 9

Primer pair 1

Microarray probesets 4

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MGI:6515786

Summaries

All 43

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 10
Earliest

J:32076 Guthridge MA, et al., Induction of expression of growth-related genes by FGF-4 in mouse fibroblasts. Oncogene. 1996 Mar 21;12(6):1267-78
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pals2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr56412	Chr6:50087166-50087275 (+)	0 bp
Tssr56413	Chr6:50087817-50087868 (+)	622 bp
Tssr56414	Chr6:50087874-50087906 (+)	669 bp
Tssr56415	Chr6:50102281-50102285 (+)	15,062 bp
Tssr56416	Chr6:50110277-50110301 (+)	23,068 bp
Tssr56417	Chr6:50121667-50121678 (+)	34,452 bp
Tssr56418	Chr6:50121707-50121728 (+)	34,497 bp
Tssr56419	Chr6:50167035-50167039 (+)	79,816 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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