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Rhbg Gene Detail
Summary
  • Symbol
    Rhbg
  • Name
    Rhesus blood group-associated B glycoprotein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927379
    NCBI Gene: 58176
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:88150181-88162016 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 38.78 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    366 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927379
 protein coding gene Chr3:88150181-88162046 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027385
 protein coding gene Chr3:88391152-88402987 (-)
A/J MGP_AJ_G0027349
 protein coding gene Chr3:85393530-85405365 (-)
AKR/J MGP_AKRJ_G0027315
 protein coding gene Chr3:87488392-87500225 (-)
BALB/cJ MGP_BALBcJ_G0027358
 protein coding gene Chr3:85483699-85495534 (-)
C3H/HeJ MGP_C3HHeJ_G0027101
 protein coding gene Chr3:87774600-87786435 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027804
 protein coding gene Chr3:91641835-91653670 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025157
 protein coding gene Chr3:81017188-81028836 (-)
CAST/EiJ MGP_CASTEiJ_G0026547
 protein coding gene Chr3:87983930-87995640 (-)
CBA/J MGP_CBAJ_G0027076
 protein coding gene Chr3:94766835-94778670 (-)
DBA/2J MGP_DBA2J_G0027212
 protein coding gene Chr3:84880653-84892488 (-)
FVB/NJ MGP_FVBNJ_G0027181
 protein coding gene Chr3:83153397-83165232 (-)
LP/J MGP_LPJ_G0027320
 protein coding gene Chr3:89358138-89369973 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027200
 protein coding gene Chr3:100997509-101009344 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027862
 protein coding gene Chr3:87248342-87260177 (-)
PWK/PhJ MGP_PWKPhJ_G0026280
 protein coding gene Chr3:84677262-84689660 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026098
 protein coding gene Chr3:86427276-86439086 (-)
WSB/EiJ MGP_WSBEiJ_G0026627
 protein coding gene Chr3:87604866-87616699 (-)



Homology
more
  • Human Ortholog
    RHBG, Rh family B glycoprotein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RHBG, Rh family B glycoprotein
  • Synonyms
    SLC42A2
  • Links
    NCBI Gene ID: 57127
    neXtProt AC: NX_Q9H310
    UniProt: Q9H310

  • Chr Location
    1q22; chr1:156369211-156385219 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable, do not develop hyperammonemic hepatic encephalopathy or distal tubular acidosis, and show a normal renal response to chronic acid-loading and no changes in NH4+ or NH3 entry across the basolateral membrane of cortical collecting ducts cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    855
  • Tissues
    149
  • cDNA Data
    12
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000104445 Ensembl Gene Model | MGI Sequence Detail 11836 C57BL/6J ±  kb
    transcript ENSMUST00000171887 Ensembl | MGI Sequence Detail 1937 Not Applicable  
    polypeptide ENSMUSP00000130767 Ensembl | MGI Sequence Detail 455 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 2
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 13
      Phenotypes 17
    • Earliest
      J:63941 Liu Z, et al., Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis. J Biol Chem. 2000 Aug 18;275(33):25641-51
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory