Herpud1 MGI Mouse Gene Detail - MGI:1927406 - homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1

Symbol

Herpud1
Name

homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
Synonyms

Herp, Mifl

Feature Type

protein coding gene
IDs

MGI:1927406
NCBI Gene: 64209
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr8:95113066-95122005 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 46.46 cM, cytoband C5
Mapping Data

1 experiment

SNPs within 2kb

320 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927406	protein coding gene	Chr8:95113057-95122005 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033960	protein coding gene	Chr8:95807062-95815996 (+)
A/J	MGP_AJ_G0033943	protein coding gene	Chr8:92070422-92079362 (+)
AKR/J	MGP_AKRJ_G0033869	protein coding gene	Chr8:94591973-94600914 (+)
BALB/cJ	MGP_BALBcJ_G0033935	protein coding gene	Chr8:92165344-92174275 (+)
C3H/HeJ	MGP_C3HHeJ_G0033645	protein coding gene	Chr8:95299343-95308281 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034456	protein coding gene	Chr8:99297839-99306760 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031397	protein coding gene	Chr8:85885877-85894740 (+)
CAST/EiJ	MGP_CASTEiJ_G0032977	protein coding gene	Chr8:94896522-94905502 (+)
CBA/J	MGP_CBAJ_G0033621	protein coding gene	Chr8:102588167-102597105 (+)
DBA/2J	MGP_DBA2J_G0033775	protein coding gene	Chr8:91539509-91548449 (+)
FVB/NJ	MGP_FVBNJ_G0033722	protein coding gene	Chr8:90506616-90515542 (+)
LP/J	MGP_LPJ_G0033867	protein coding gene	Chr8:95954847-95963791 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033764	protein coding gene	Chr8:104887546-104896545 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034474	protein coding gene	Chr8:94756070-94765026 (+)
PWK/PhJ	MGP_PWKPhJ_G0032679	protein coding gene	Chr8:90917280-90926193 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032516	protein coding gene	Chr8:93580101-93589070 (+)
WSB/EiJ	MGP_WSBEiJ_G0033089	protein coding gene	Chr8:95274985-95283963 (+)

Human Ortholog

HERPUD1, homocysteine inducible ER protein with ubiquitin like domain 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HERPUD1, homocysteine inducible ER protein with ubiquitin like domain 1
Synonyms

HERP, Mif1, SUP
Links

HGNC:13744

NCBI Gene ID: 9709

neXtProt AC: NX_Q15011

UniProt: Q15011
Chr Location

16q13; chr16:56932142-56944864 (+) GRCh38

MGI Vertebrate Homology

Herpud1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HERPUD1
Gene Tree

Herpud1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
1 images
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Targeted

3
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired glucose tolerance and decreased cerebral infarction size.

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All GO Annotations

42
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

760
Tissues

9
cDNA Data

243
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase herpud1

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All Sequences

64
RefSeq

6
UniProt

9
CCDS

CCDS22541.1, CCDS90439.1

Ensembl

ENSMUSG00000031770 (Evidence)
NCBI Gene

64209

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031770	Ensembl Gene Model \| MGI Sequence Detail	8940	C57BL/6J	± kb
transcript	ENSMUST00000161576	Ensembl \| MGI Sequence Detail	1952	Not Applicable
polypeptide	ENSMUSP00000124201	Ensembl \| MGI Sequence Detail	391	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000008513 homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

(term hierarchy)
InterPro Domains

IPR039751 Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 /2

IPR000626 Ubiquitin-like domain

IPR029071 Ubiquitin-like domain superfamily

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All nucleic 246

cDNA 243

Primer pair 3

Microarray probesets 3

Summaries

All 51

Developmental Gene Expression 12

Gene Ontology 11

Phenotypes 7
Earliest

J:65186 Kokame K, et al., Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress. J Biol Chem. 2000 Oct 20;275(42):32846-53
Latest

J:354587 Nedomova M, et al., DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. iScience. 2024 Oct 18;27(10):110893

TSS for Herpud1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78853	Chr8:95112795-95112802 (+)	-267 bp
Tssr78854	Chr8:95112806-95112834 (+)	-246 bp
Tssr78855	Chr8:95113095-95113096 (+)	30 bp
Tssr78856	Chr8:95113114-95113137 (+)	60 bp
Tssr78857	Chr8:95113138-95113147 (+)	77 bp
Tssr78858	Chr8:95113151-95113162 (+)	91 bp
Tssr78859	Chr8:95114821-95114826 (+)	1,758 bp
Tssr78860	Chr8:95120172-95120176 (+)	7,108 bp
Tssr78861	Chr8:95121442-95121455 (+)	8,383 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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