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Lsr Gene Detail
Summary
  • Symbol
    Lsr
  • Name
    lipolysis stimulated lipoprotein receptor
  • Synonyms
    ILDR3, Lisch7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927471
    NCBI Gene: 54135
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30657195-30672889 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 19.27 cM, cytoband A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    449 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927471
 protein coding gene Chr7:30657195-30672894 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032054
 protein coding gene Chr7:30012355-30028052 (-)
A/J MGP_AJ_G0032031
 protein coding gene Chr7:29201740-29217432 (-)
AKR/J MGP_AKRJ_G0031964
 protein coding gene Chr7:29941435-29957127 (-)
BALB/cJ MGP_BALBcJ_G0032038
 protein coding gene Chr7:29372529-29388221 (-)
C3H/HeJ MGP_C3HHeJ_G0031755
 protein coding gene Chr7:30391460-30407154 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032504
 protein coding gene Chr7:31019313-31035007 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029554
 protein coding gene Chr7:30159212-30174034 (-)
CAST/EiJ MGP_CASTEiJ_G0031091
 protein coding gene Chr7:23655121-23670692 (-)
CBA/J MGP_CBAJ_G0031723
 protein coding gene Chr7:32470085-32485779 (-)
DBA/2J MGP_DBA2J_G0031875
 protein coding gene Chr7:28917277-28933031 (-)
FVB/NJ MGP_FVBNJ_G0031831
 protein coding gene Chr7:29034675-29050369 (-)
LP/J MGP_LPJ_G0031956
 protein coding gene Chr7:30349807-30365498 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031868
 protein coding gene Chr7:31706675-31722367 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032530
 protein coding gene Chr7:29450229-29465981 (-)
PWK/PhJ MGP_PWKPhJ_G0030813
 protein coding gene Chr7:23953078-23969001 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030650
 protein coding gene Chr7:20438645-20454405 (-)
WSB/EiJ MGP_WSBEiJ_G0031201
 protein coding gene Chr7:29844616-29860325 (-)



Homology
more
  • Human Ortholog
    LSR, lipolysis stimulated lipoprotein receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LSR, lipolysis stimulated lipoprotein receptor
  • Synonyms
    ILDR3, LISCH7
  • Links
    NCBI Gene ID: 51599
    neXtProt AC: NX_Q86X29
    UniProt: Q86X29

  • Chr Location
    19q13.12; chr19:35248330-35267964 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality during fetal growth and development, liver hypoplasia, and variable penetrance of pallor, hemorrhaging, superficial skin detachment, and reduced size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1022
  • Tissues
    118
  • cDNA Data
    10
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001247 Ensembl Gene Model | MGI Sequence Detail 15695 C57BL/6J ±  kb
    transcript ENSMUST00000001279 Ensembl | MGI Sequence Detail 2167 Not Applicable  
    polypeptide ENSMUSP00000001279 Ensembl | MGI Sequence Detail 594 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 10
      Primer pair 5
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 17
      Gene Ontology 12
      Phenotypes 16
    • Earliest
      J:20532 Lin Q, et al., Archaic structure of the gene encoding transcription factor USF. J Biol Chem. 1994 Sep 30;269(39):23894-903
    • Latest
      J:347596 Higashi AY, et al., Bicellular Localization of Tricellular Junctional Protein Angulin-3/ILDR2 Allows Detection of Podocyte Injury. Am J Pathol. 2024 May;194(5):673-683
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory