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Pdlim5 Gene Detail
Summary
  • Symbol
    Pdlim5
  • Name
    PDZ and LIM domain 5
  • Synonyms
    1110001A05Rik, Enh, Enh2, Enh3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927489
    NCBI Gene: 56376
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:141945351-142101454 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 66.69 cM, cytoband H3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4291 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927489
 protein coding gene Chr3:141945346-142101480 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027940
 protein coding gene Chr3:145407019-145571538 (-)
A/J MGP_AJ_G0027897
 protein coding gene Chr3:140268037-140424710 (-)
AKR/J MGP_AKRJ_G0027863
 protein coding gene Chr3:143973056-144130983 (-)
BALB/cJ MGP_BALBcJ_G0027909
 protein coding gene Chr3:140074077-140233491 (-)
C3H/HeJ MGP_C3HHeJ_G0027639
 protein coding gene Chr3:144324032-144481334 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028353
 protein coding gene Chr3:150476335-150637022 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025691
 protein coding gene Chr3:135510561-135670039 (-)
CAST/EiJ MGP_CASTEiJ_G0027095
 protein coding gene Chr3:144230994-144401418 (-)
CBA/J MGP_CBAJ_G0027616
 protein coding gene Chr3:155654846-155830269 (-)
DBA/2J MGP_DBA2J_G0027755
 protein coding gene Chr3:139397966-139560632 (-)
FVB/NJ MGP_FVBNJ_G0027722
 protein coding gene Chr3:136818041-136981154 (-)
LP/J MGP_LPJ_G0027865
 protein coding gene Chr3:146852133-147013785 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027754
 protein coding gene Chr3:163957528-164148797 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028411
 protein coding gene Chr3:143585511-143744301 (-)
PWK/PhJ MGP_PWKPhJ_G0026819
 protein coding gene Chr3:139199437-139362778 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026646
 protein coding gene Chr3:141696140-141860603 (-)
WSB/EiJ MGP_WSBEiJ_G0027174
 protein coding gene Chr3:144447052-144608949 (-)



Homology
more
  • Human Ortholog
    PDLIM5, PDZ and LIM domain 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDLIM5, PDZ and LIM domain 5
  • Synonyms
    ENH, ENH1, L9, LIM
  • Links
    NCBI Gene ID: 10611
    neXtProt AC: NX_Q96HC4
    UniProt: Q96HC4

  • Chr Location
    4q22.3; chr4:94451857-94668227 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Pdlim5 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired cardiac muscle contractility, wider Z-lines, and dilated cardiomyopathy. Mice heterozygous for a gene trap allele exhibit impaired response to methamphetamine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    859
  • Tissues
    54
  • cDNA Data
    21
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028273 Ensembl Gene Model | MGI Sequence Detail 156104 C57BL/6J ±  kb
    transcript ENSMUST00000195975 Ensembl | MGI Sequence Detail 1845 Not Applicable  
    polypeptide ENSMUSP00000142737 Ensembl | MGI Sequence Detail 614 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 23
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1914158, MGI:1927491, MGI:1927492, MGI:2139847, MGI:2140101
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory