Dipk1b Gene Detail

Summary

• Symbol
  Dipk1b
• Name
  divergent protein kinase domain 1B
• Synonyms
  B230317C12Rik, Fam69b, PIP49

• Feature Type
  protein coding gene
• IDs
  MGI:1927576
  NCBI Gene: 56279
• Alliance
  gene page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr2:26518469-26526509 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 2, 18.97 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  262 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927576	protein coding gene	Chr2:26518469-26526509 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025494	protein coding gene	Chr2:24601001-24609041 (+)
A/J	MGP_AJ_G0025471	protein coding gene	Chr2:23650277-23658305 (+)
AKR/J	MGP_AKRJ_G0025441	protein coding gene	Chr2:24420491-24428519 (+)
BALB/cJ	MGP_BALBcJ_G0025467	protein coding gene	Chr2:23760844-23768967 (+)
C3H/HeJ	MGP_C3HHeJ_G0025228	protein coding gene	Chr2:24375118-24383158 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025911	protein coding gene	Chr2:25399492-25407384 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023322	protein coding gene	Chr2:22526045-22533836 (+)
CAST/EiJ	MGP_CASTEiJ_G0024691	protein coding gene	Chr2:24253071-24260927 (+)
CBA/J	MGP_CBAJ_G0025206	protein coding gene	Chr2:26237157-26248274 (+)
DBA/2J	MGP_DBA2J_G0025339	protein coding gene	Chr2:23468885-23476913 (+)
FVB/NJ	MGP_FVBNJ_G0025301	protein coding gene	Chr2:23228042-23236082 (+)
LP/J	MGP_LPJ_G0025425	protein coding gene	Chr2:24534510-24542550 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025332	protein coding gene	Chr2:26377521-26385561 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025970	protein coding gene	Chr2:24372519-24380559 (+)
PWK/PhJ	MGP_PWKPhJ_G0024439	protein coding gene	Chr2:23279071-23287199 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024239	protein coding gene	Chr2:24510028-24517791 (+)
WSB/EiJ	MGP_WSBEiJ_G0024760	protein coding gene	Chr2:24481119-24489159 (+)

Homology

• Human Ortholog
  DIPK1B, divergent protein kinase domain 1B

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  DIPK1B, divergent protein kinase domain 1B
  
• Synonyms
  C9orf136, FAM69B, pp6977
• Links
  HGNC:28290

  NCBI Gene ID: 138311

  neXtProt AC: NX_Q5VUD6

  UniProt: Q5VUD6

  
  
• Chr Location
  9q34.3; chr9:136712572-136724742 (+)  GRCh38

---

• MGI Vertebrate Homology
  Dipk1b stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: DIPK1B
• Gene Tree
  Dipk1b
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotype references
  

• All Mutations and Alleles
  4
• Endonuclease-mediated
  1
• Gene trapped
  1
• Targeted
  2
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  21 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  1
• GO References
  1

Expression

• Assay Results
  716
• Tissues
  5
• cDNA Data
  30
• Literature Summary
  1

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase dipk1b
  ZFIN dipk1b

Sequences &
Gene Models

• All Sequences
  41
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS50542.1

• Ensembl
  ENSMUSG00000036186 (Evidence)
• NCBI Gene
  56279

Representative Sequences			Length	Strain/Species
genomic	56279	NCBI Gene Model | MGI Sequence Detail	8041	C57BL/6J
transcript	NM_019833	RefSeq | MGI Sequence Detail	1636	C57BL/6
polypeptide	Q99ML4	UniProt | EBI | MGI Sequence Detail	431	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000031740 divergent protein kinase domain 1B
  (term hierarchy)
• InterPro Domains
  IPR029244 FAM69, N-terminal
  IPR022049 FAM69, protein-kinase domain

Molecular
Reagents

• All nucleic 31

  cDNA 30

  Primer pair 1

  
  

  Microarray probesets 4

Other
Accession IDs

MGI:2139324, MGI:6276590

References

• Summaries
  All 30

  Developmental Gene Expression 1

  Gene Ontology 1

  Phenotypes 6
• Earliest
  J:64911 Inoue S, et al., Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains. Biochem Biophys Res Commun. 2000 Feb 16;268(2):553-61
• Latest
  J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Dipk1b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr16816	Chr2:26518453-26518474 (+)	-5 bp
Tssr16817	Chr2:26518477-26518562 (+)	51 bp
Tssr16818	Chr2:26520516-26520540 (+)	2,059 bp