Itm2c MGI Mouse Gene Detail - MGI:1927594 - integral membrane protein 2C

Symbol

Itm2c
Name

integral membrane protein 2C
Synonyms

3110038L02Rik, BRI3, Bricd2c, ITM3

Feature Type

protein coding gene
IDs

MGI:1927594
NCBI Gene: 64294
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:85822231-85836419 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 43.94 cM
Mapping Data

2 experiments

SNPs within 2kb

431 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927594	protein coding gene	Chr1:85822002-85836419 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016236	protein coding gene	Chr1:87113613-87128008 (+)
A/J	MGP_AJ_G0016217	protein coding gene	Chr1:83896867-83911260 (+)
AKR/J	MGP_AKRJ_G0016178	protein coding gene	Chr1:86321713-86336095 (+)
BALB/cJ	MGP_BALBcJ_G0016174	protein coding gene	Chr1:84012033-84026430 (+)
C3H/HeJ	MGP_C3HHeJ_G0016002	protein coding gene	Chr1:86583461-86597900 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016630	protein coding gene	Chr1:90446302-90460710 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014352	protein coding gene	Chr1:78390303-78404813 (+)
CAST/EiJ	MGP_CASTEiJ_G0015587	protein coding gene	Chr1:85812835-85829695 (+)
CBA/J	MGP_CBAJ_G0015978	protein coding gene	Chr1:93246972-93264033 (+)
DBA/2J	MGP_DBA2J_G0016080	protein coding gene	Chr1:83205828-83220230 (+)
FVB/NJ	MGP_FVBNJ_G0016080	protein coding gene	Chr1:82250160-82264903 (+)
LP/J	MGP_LPJ_G0016152	protein coding gene	Chr1:88225680-88240127 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016106	protein coding gene	Chr1:96549137-96563525 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016673	protein coding gene	Chr1:86450083-86464486 (+)
PWK/PhJ	MGP_PWKPhJ_G0015374	protein coding gene	Chr1:82486841-82501657 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015154	protein coding gene	Chr1:85437924-85452391 (+)
WSB/EiJ	MGP_WSBEiJ_G0015651	protein coding gene	Chr1:86098470-86112910 (+)

Human Ortholog

ITM2C, integral membrane protein 2C

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ITM2C, integral membrane protein 2C
Synonyms

BRI3, BRICD2C, E25, E25C, ITM3
Links

HGNC:6175

NCBI Gene ID: 81618

neXtProt AC: NX_Q9NQX7

UniProt: Q9NQX7
Chr Location

2q37.1; chr2:230864185-230879254 (+) GRCh38

MGI Vertebrate Homology

Itm2c stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ITM2C
Gene Tree

Itm2c

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Phenotype Summary

4 phenotypes from 3 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

5
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Itm2c
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable, fertile and overtly normal with no alterations in the development, maturation and differentiation of B-lymphocytes or production of antibodies by antibody secreting cells.

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All GO Annotations

21
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

739
Tissues

33
cDNA Data

270
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN itm2ca

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All Sequences

74
RefSeq

2
UniProt

3
CCDS

CCDS35641.1

Ensembl

ENSMUSG00000026223 (Evidence)
NCBI Gene

64294

			Length	Strain/Species	Flank
genomic	64294	NCBI Gene Model \| MGI Sequence Detail	14189	C57BL/6J	± kb
transcript	NM_022417	RefSeq \| MGI Sequence Detail	2024	C57BL/6
polypeptide	Q91VK4	UniProt \| EBI \| MGI Sequence Detail	269	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000031384 integral membrane protein 2C

(term hierarchy)
InterPro Domains

IPR007084 BRICHOS domain

IPR040145 Integral membrane protein 2
GlyGen

Q91VK4 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 271

cDNA 270

Other 1

Microarray probesets 3

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MGI:1924235, MGI:2138489, MGI:2138734

Summaries

All 52

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 17
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Itm2c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7700	Chr1:85822170-85822175 (+)	-58 bp
Tssr7701	Chr1:85822252-85822376 (+)	83 bp
Tssr7702	Chr1:85830817-85830837 (+)	8,596 bp
Tssr7703	Chr1:85832304-85832307 (+)	10,075 bp
Tssr7704	Chr1:85834137-85834153 (+)	11,914 bp
Tssr7705	Chr1:85834729-85834742 (+)	12,505 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24