Dnaja4 MGI Mouse Gene Detail - MGI:1927638 - DnaJ heat shock protein family (Hsp40) member A4

Symbol

Dnaja4
Name

DnaJ heat shock protein family (Hsp40) member A4
Synonyms

1110021L12Rik, Dj4, Hsj4

Feature Type

protein coding gene
IDs

MGI:1927638
NCBI Gene: 58233
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr9:54606157-54623599 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 29.72 cM
Mapping Data

3 experiments

SNPs within 2kb

491 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927638	protein coding gene	Chr9:54606132-54623601 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034828	protein coding gene	Chr9:53757881-53775353 (+)
A/J	MGP_AJ_G0034809	protein coding gene	Chr9:52037012-52054454 (+)
AKR/J	MGP_AKRJ_G0034738	protein coding gene	Chr9:53217590-53235030 (+)
BALB/cJ	MGP_BALBcJ_G0034801	protein coding gene	Chr9:51811533-51828975 (+)
C3H/HeJ	MGP_C3HHeJ_G0034511	protein coding gene	Chr9:53683236-53700678 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035320	protein coding gene	Chr9:55259868-55277308 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032232	protein coding gene	Chr9:51454449-51470385 (+)
CAST/EiJ	MGP_CASTEiJ_G0033833	protein coding gene	Chr9:53706384-53723945 (+)
CBA/J	MGP_CBAJ_G0034482	protein coding gene	Chr9:57172559-57190044 (+)
DBA/2J	MGP_DBA2J_G0034641	protein coding gene	Chr9:51929041-51946477 (+)
FVB/NJ	MGP_FVBNJ_G0034583	protein coding gene	Chr9:51130704-51148144 (+)
LP/J	MGP_LPJ_G0034724	protein coding gene	Chr9:54070755-54088227 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034626	protein coding gene	Chr9:58717023-58734465 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035342	protein coding gene	Chr9:53226075-53243515 (+)
PWK/PhJ	MGP_PWKPhJ_G0033537	protein coding gene	Chr9:51910994-51928785 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033372	protein coding gene	Chr9:53493738-53511290 (+)
WSB/EiJ	MGP_WSBEiJ_G0033945	protein coding gene	Chr9:53199999-53217446 (+)

Human Ortholog

DNAJA4, DnaJ heat shock protein family (Hsp40) member A4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNAJA4, DnaJ heat shock protein family (Hsp40) member A4
Synonyms

MST104, MSTP104, PRO1472
Links

HGNC:14885

NCBI Gene ID: 55466

neXtProt AC: NX_Q8WW22

UniProt: Q8WW22
Chr Location

15q25.1; chr15:78264086-78282196 (+) GRCh38

MGI Vertebrate Homology

Dnaja4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DNAJA4
Gene Tree

Dnaja4

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Targeted

5
Incidental Mutations

CvDC
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

23
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

810
Tissues

40
cDNA Data

11
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dnaja4, dnaja4.2

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All Sequences

54
RefSeq

6
UniProt

5
CCDS

CCDS23193.1

Ensembl

ENSMUSG00000032285 (Evidence)
NCBI Gene

58233

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032285	Ensembl Gene Model \| MGI Sequence Detail	17443	C57BL/6J	± kb
transcript	ENSMUST00000120452	Ensembl \| MGI Sequence Detail	1827	Not Applicable
polypeptide	ENSMUSP00000112520	Ensembl \| MGI Sequence Detail	397	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000029421 DnaJ homolog subfamily A member 4

(term hierarchy)
InterPro Domains

IPR012724 Chaperone DnaJ

IPR002939 Chaperone DnaJ, C-terminal

IPR036869 Chaperone J-domain superfamily

IPR001623 DnaJ domain

IPR018253 DnaJ domain, conserved site

IPR044713 DnaJ homolog subfamily A member 1/2-like

IPR001305 Heat shock protein DnaJ, cysteine-rich domain

IPR036410 Heat shock protein DnaJ, cysteine-rich domain superfamily

IPR008971 HSP40/DnaJ peptide-binding
GlyGen

Q9JMC3 1 site, 1 N-linked glycan (1 site)

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All nucleic 11

cDNA 11

Microarray probesets 6

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MGI:1913407, MGI:2143273

Summaries

All 37

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 8
Earliest

J:64474 Hata M, et al., Murine cDNA encoding a novel type I HSP40/DNAJ homolog, mmDjA4(1). Biochim Biophys Acta. 2000 Sep 7;1493(1-2):208-10
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dnaja4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85165	Chr9:54606143-54606168 (+)	-1 bp
Tssr85166	Chr9:54606174-54606180 (+)	20 bp
Tssr85167	Chr9:54606184-54606191 (+)	31 bp
Tssr85168	Chr9:54606205-54606211 (+)	51 bp
Tssr85169	Chr9:54606410-54606424 (+)	260 bp
Tssr85170	Chr9:54606802-54606809 (+)	649 bp
Tssr85171	Chr9:54606832-54606849 (+)	684 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24