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Gpr88 Gene Detail
Summary
  • Symbol
    Gpr88
  • Name
    G-protein coupled receptor 88
  • Synonyms
    Strg
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927653
    NCBI Gene: 64378
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:116043304-116047123 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 50.23 cM, cytoband G1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    155 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927653
 protein coding gene Chr3:116043303-116047152 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027808
 protein coding gene Chr3:118139414-118143267 (-)
A/J MGP_AJ_G0027766
 protein coding gene Chr3:114264954-114268809 (-)
AKR/J MGP_AKRJ_G0027732
 protein coding gene Chr3:117158687-117162542 (-)
BALB/cJ MGP_BALBcJ_G0027778
 protein coding gene Chr3:114114852-114118705 (-)
C3H/HeJ MGP_C3HHeJ_G0027509
 protein coding gene Chr3:117521267-117525120 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028224
 protein coding gene Chr3:122475169-122479016 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025563
 protein coding gene Chr3:109964814-109968690 (-)
CAST/EiJ MGP_CASTEiJ_G0026965
 protein coding gene Chr3:116801683-116805562 (-)
CBA/J MGP_CBAJ_G0027484
 protein coding gene Chr3:126652175-126656028 (-)
DBA/2J MGP_DBA2J_G0027625
 protein coding gene Chr3:113504018-113507871 (-)
FVB/NJ MGP_FVBNJ_G0027593
 protein coding gene Chr3:111148383-111152236 (-)
LP/J MGP_LPJ_G0027735
 protein coding gene Chr3:119681403-119685256 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027623
 protein coding gene Chr3:134020452-134024309 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028280
 protein coding gene Chr3:116699583-116703436 (-)
PWK/PhJ MGP_PWKPhJ_G0026691
 protein coding gene Chr3:113149349-113153223 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026513
 protein coding gene Chr3:114626855-114711880 (-)
WSB/EiJ MGP_WSBEiJ_G0027045
 protein coding gene Chr3:117382854-117386713 (-)



Homology
more
  • Human Ortholog
    GPR88, G protein-coupled receptor 88
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR88, G protein-coupled receptor 88
  • Synonyms
    COCPMR, STRG
  • Links
    NCBI Gene ID: 54112
    neXtProt AC: NX_Q9GZN0
    UniProt: Q9GZN0

  • Chr Location
    1p21.2; chr1:100538139-100542021 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 2 alleles in 2 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show enhanced medium spiny neuron activity, hyperactivity, impaired motor coordination, and altered motor- and cue-based learning. Homozygotes for a different null allele show a motor skill deficit, enhanced spatial learning, stereotypies, and lower anxiety levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    888
  • Tissues
    167
  • cDNA Data
    14
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 64378 NCBI Gene Model | MGI Sequence Detail 3820 C57BL/6J ±  kb
    transcript NM_001411426 RefSeq | MGI Sequence Detail 3498 C57BL/6  
    polypeptide Q9EPB7 UniProt | EBI | MGI Sequence Detail 384 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 14
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2139966
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 9
      Phenotypes 28
    • Earliest
      J:65631 Mizushima K, et al., A novel G-protein-coupled receptor gene expressed in striatum. Genomics. 2000 Nov 1;69(3):314-21
    • Latest
      J:334081 Mansky RH, et al., Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington's disease. Cell Rep. 2023 Mar 2;42(3):112198
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory