Sirt2 MGI Mouse Gene Detail - MGI:1927664

Symbol

Sirt2
Name

sirtuin 2
Synonyms

5730427M03Rik, Sir2l, SIR2L2

Feature Type

protein coding gene
IDs

MGI:1927664
NCBI Gene: 64383
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr7:28466192-28488086 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 16.92 cM, cytoband B1-2
Mapping Data

2 experiments

SNPs within 2kb

644 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927664	protein coding gene	Chr7:28466160-28488086 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031960	protein coding gene	Chr7:27605646-27629756 (+)
A/J	MGP_AJ_G0031938	protein coding gene	Chr7:26915295-26937221 (+)
AKR/J	MGP_AKRJ_G0031870	protein coding gene	Chr7:27606364-27628296 (+)
BALB/cJ	MGP_BALBcJ_G0031945	protein coding gene	Chr7:27073428-27095993 (+)
C3H/HeJ	MGP_C3HHeJ_G0031664	protein coding gene	Chr7:27982056-28003954 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032409	protein coding gene	Chr7:28505874-28529391 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029461	protein coding gene	Chr7:27974822-27999654 (+)
CAST/EiJ	MGP_CASTEiJ_G0030999	protein coding gene	Chr7:21301806-21325380 (+)
CBA/J	MGP_CBAJ_G0031630	protein coding gene	Chr7:29773881-29796266 (+)
DBA/2J	MGP_DBA2J_G0031782	protein coding gene	Chr7:26666487-26688369 (+)
FVB/NJ	MGP_FVBNJ_G0031739	protein coding gene	Chr7:26745130-26766834 (+)
LP/J	MGP_LPJ_G0031862	protein coding gene	Chr7:27926606-27948990 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031775	protein coding gene	Chr7:29245137-29267992 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032439	protein coding gene	Chr7:27084867-27106796 (+)
PWK/PhJ	MGP_PWKPhJ_G0030724	protein coding gene	Chr7:21691000-21713857 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030557	protein coding gene	Chr7:18105062-18128906 (+)
WSB/EiJ	MGP_WSBEiJ_G0031108	protein coding gene	Chr7:27457008-27479805 (+)

Human Ortholog

SIRT2, sirtuin 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SIRT2, sirtuin 2
Synonyms

SIR2, SIR2L, SIR2L2
Links

HGNC:10886

NCBI Gene ID: 22933

neXtProt AC: NX_Q8IXJ6

UniProt: Q8IXJ6
Chr Location

19q13.2; chr19:38878555-38899862 (-) GRCh38

MGI Vertebrate Homology

Sirt2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SIRT2
Protein SuperFamily

SIR2_euk
Gene Tree

Sirt2

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Phenotype Summary

28 phenotypes from 6 alleles in 9 genetic backgrounds
7 phenotypes from multigenic genotypes
4 images
67 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Endonuclease-mediated

4
Gene trapped

3
Targeted

10
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a floxed allele activated in Schwann cells exhibit delayed myelination during development and following a nerve crush injury. Mice homozygous for a knock-out allele exhibit increased tumor formation and abnormal mitosis.

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All GO Annotations

174
GO References

26

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

799
Tissues

24
cDNA Data

10
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sirt2

ZFIN sirt2

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All Sequences

73
RefSeq

8
UniProt

3
CCDS

CCDS21055.1, CCDS52165.1, CCDS85253.1

Ensembl

ENSMUSG00000015149 (Evidence)
NCBI Gene

64383

			Length	Strain/Species	Flank
genomic	64383	NCBI Gene Model \| MGI Sequence Detail	21895	C57BL/6J	± kb
transcript	NM_022432	RefSeq \| MGI Sequence Detail	1843	C57BL/6
polypeptide	Q8VDQ8	UniProt \| EBI \| MGI Sequence Detail	389	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014889 NAD-dependent protein deacetylase sirtuin-2

(term hierarchy)
EC

2.3.1.-, 2.3.1.286
InterPro Domains

IPR029035 DHS-like NAD/FAD-binding domain superfamily

IPR050134 NAD-dependent sirtuin protein deacylases

IPR026591 Sirtuin, catalytic core small domain superfamily

IPR017328 Sirtuin, class I

IPR003000 Sirtuin family

IPR026590 Sirtuin family, catalytic core domain
GlyGen

Q8VDQ8 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 13

Genomic 1

cDNA 10

Primer pair 2

Microarray probesets 3

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MGI:1915014

Summaries

All 151

Developmental Gene Expression 7

Gene Ontology 26

Phenotypes 67
Earliest

J:65632 Yang YH, et al., Cloning and characterization of two mouse genes with homology to the yeast sir2 gene. Genomics. 2000 Nov 1;69(3):355-69
Latest

J:354193 Nevoral J, et al., Dynamics and necessity of SIRT1 for maternal-zygotic transition. Sci Rep. 2024 Sep 16;14(1):21598

TSS for Sirt2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65507	Chr7:28465701-28465748 (+)	-467 bp
Tssr65508	Chr7:28466172-28466247 (+)	18 bp
Tssr65509	Chr7:28466262-28466274 (+)	76 bp
Tssr65510	Chr7:28466646-28466651 (+)	457 bp
Tssr65511	Chr7:28466658-28466669 (+)	472 bp
Tssr65512	Chr7:28467051-28467067 (+)	867 bp
Tssr65513	Chr7:28469199-28469207 (+)	3,011 bp
Tssr65514	Chr7:28480989-28481002 (+)	14,804 bp
Tssr65515	Chr7:28483778-28483790 (+)	17,592 bp
Tssr65516	Chr7:28484790-28484809 (+)	18,608 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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