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Cyp4f14 Gene Detail
Summary
  • Symbol
    Cyp4f14
  • Name
    cytochrome P450, family 4, subfamily f, polypeptide 14
  • Synonyms
    1300014O15Rik, leukotriene B4 omega hydroxylase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927669
    NCBI Gene: 64385
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:33124044-33136316 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    465 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927669
 protein coding gene Chr17:33122331-33136353 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023515
 protein coding gene Chr17:32796556-32809178 (-)
A/J MGP_AJ_G0023473
 protein coding gene Chr17:31703942-31716108 (-)
AKR/J MGP_AKRJ_G0023439
 protein coding gene Chr17:32013261-32029358 (-)
BALB/cJ MGP_BALBcJ_G0023478
 protein coding gene Chr17:31802216-31814524 (-)
C3H/HeJ MGP_C3HHeJ_G0023240
 protein coding gene Chr17:32413271-32425086 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023921
 protein coding gene Chr17:33918218-33931561 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021395
 protein coding gene Chr17:28970899-28983051 (-)
CAST/EiJ MGP_CASTEiJ_G0022741
 protein coding gene Chr17:32519831-32531913 (-)
CBA/J MGP_CBAJ_G0023214
 protein coding gene Chr17:35423339-35435537 (-)
DBA/2J MGP_DBA2J_G0023344
 protein coding gene Chr17:31089006-31101436 (-)
FVB/NJ MGP_FVBNJ_G0023314
 protein coding gene Chr17:30901757-30914252 (-)
LP/J MGP_LPJ_G0023423
 protein coding gene Chr17:33015429-33029044 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023333
 protein coding gene Chr17:34412284-34424488 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023963
 protein coding gene Chr17:32381373-32394760 (-)
PWK/PhJ MGP_PWKPhJ_G0022488
 protein coding gene Chr17:30011488-30024041 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022308
 protein coding gene Chr17:30353040-30369902 (-)
WSB/EiJ MGP_WSBEiJ_G0022802
 protein coding gene Chr17:32395095-32408194 (-)



Homology
more
  • Human Ortholog
    CYP4F11, cytochrome P450 family 4 subfamily F member 11
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP4F11, cytochrome P450 family 4 subfamily F member 11
  • Synonyms
    CYPIVF11
  • Links
    NCBI Gene ID: 57834
    neXtProt AC: NX_Q9HBI6
    UniProt: Q9HBI6

  • Chr Location
    19p13.12; chr19:15912367-15934867 (-)  GRCh38
  • Human Ortholog
    CYP4F12, cytochrome P450 family 4 subfamily F member 12
  • Synonyms
    CYPIVF12, F22329_1
  • Links
    NCBI Gene ID: 66002
    neXtProt AC: NX_Q9HCS2
    UniProt: Q9HCS2

  • Chr Location
    19p13.12; chr19:15673018-15697174 (+)  GRCh38
  • Human Ortholog
    CYP4F2, cytochrome P450 family 4 subfamily F member 2
  • Synonyms
    CPF2
  • Links
    NCBI Gene ID: 8529
    neXtProt AC: NX_P78329
    UniProt: P78329

  • Chr Location
    19p13.12; chr19:15878023-15898077 (-)  GRCh38
  • Human Ortholog
    CYP4F8, cytochrome P450 family 4 subfamily F member 8
  • Synonyms
    CPF8, CYPIVF8
  • Links
    NCBI Gene ID: 11283
    neXtProt AC: NX_P98187
    UniProt: P98187

  • Chr Location
    19p13.12; chr19:15615218-15630639 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CYP4F8 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced vitamin E-omega-hydroxylase activity and altered levels of tocopherols and their metabolites.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    812
  • Tissues
    106
  • cDNA Data
    40
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024292 Ensembl Gene Model | MGI Sequence Detail 12273 C57BL/6J ±  kb
    transcript ENSMUST00000235058 Ensembl | MGI Sequence Detail 2033 Not Applicable  
    polypeptide ENSMUSP00000157006 Ensembl | MGI Sequence Detail 524 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 40
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1914146, MGI:2147045
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:65964 Kikuta Y, et al., Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14. Arch Biochem Biophys. 2000 Nov 15;383(2):225-32
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory