Gpr85 MGI Mouse Gene Detail - MGI:1927851 - G protein-coupled receptor 85

Symbol

Gpr85
Name

G protein-coupled receptor 85
Synonyms

2900026B03Rik

Feature Type

protein coding gene
IDs

MGI:1927851
NCBI Gene: 64450
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr6:13834457-13839941 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 5.76 cM
Mapping Data

1 experiment

SNPs within 2kb

135 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927851	protein coding gene	Chr6:13834405-13839951 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030461	protein coding gene	Chr6:10920802-10927184 (-)
A/J	MGP_AJ_G0030434	protein coding gene	Chr6:10502371-10507841 (-)
AKR/J	MGP_AKRJ_G0030361	protein coding gene	Chr6:10853655-10859105 (-)
BALB/cJ	MGP_BALBcJ_G0030443	protein coding gene	Chr6:10486799-10492508 (-)
C3H/HeJ	MGP_C3HHeJ_G0030157	protein coding gene	Chr6:10762899-10769536 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030898	protein coding gene	Chr6:11322960-11328408 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028109	protein coding gene	Chr6:9677679-9683168 (-)
CAST/EiJ	MGP_CASTEiJ_G0029559	protein coding gene	Chr6:10610629-10616098 (-)
CBA/J	MGP_CBAJ_G0030135	protein coding gene	Chr6:11618916-11624361 (-)
DBA/2J	MGP_DBA2J_G0030279	protein coding gene	Chr6:10421232-10426695 (-)
FVB/NJ	MGP_FVBNJ_G0030233	protein coding gene	Chr6:10327747-10333206 (-)
LP/J	MGP_LPJ_G0030366	protein coding gene	Chr6:10873294-10878789 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030269	protein coding gene	Chr6:12415324-12420798 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030928	protein coding gene	Chr6:10741132-10746932 (-)
PWK/PhJ	MGP_PWKPhJ_G0029273	protein coding gene	Chr6:10118653-10124209 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029109	protein coding gene	Chr6:10613983-10619443 (-)
WSB/EiJ	MGP_WSBEiJ_G0029635	protein coding gene	Chr6:10687399-10692844 (-)

Human Ortholog

GPR85, G protein-coupled receptor 85

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPR85, G protein-coupled receptor 85
Synonyms

SREB, SREB2
Links

HGNC:4536

NCBI Gene ID: 54329

neXtProt AC: NX_P60893

UniProt: P60893
Chr Location

7q31.1; chr7:113078331-113087778 (-) GRCh38

MGI Vertebrate Homology

Gpr85 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GPR85
Gene Tree

Gpr85

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Phenotype Summary

13 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

4
Gene trapped

1
Targeted

5
Transgenic

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele display a significant increase in brain weight and enhanced contextual memory in a fear-conditioning task but no additional behavioral abnormalities.

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All GO Annotations

8
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

878
Tissues

67
cDNA Data

9
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpr85

ZFIN gpr85

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All Sequences

60
RefSeq

20
UniProt

2
CCDS

CCDS19916.1

Ensembl

ENSMUSG00000048216 (Evidence)
NCBI Gene

64450

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048216	Ensembl Gene Model \| MGI Sequence Detail	5485	C57BL/6J	± kb
transcript	ENSMUST00000060442	Ensembl \| MGI Sequence Detail	3661	Not Applicable
polypeptide	ENSMUSP00000053837	Ensembl \| MGI Sequence Detail	370	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001650 probable G-protein coupled receptor 85

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR051509 GPCR with Orphan and Phoenixin-Mediated Functions

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

P60894 3 sites

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All nucleic 11

cDNA 10

Primer pair 1

Microarray probesets 5

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MGI:1920116

Summaries

All 39

Developmental Gene Expression 7

Gene Ontology 5

Phenotypes 10
Earliest

J:64476 Hellebrand S, et al., The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31(1). Biochim Biophys Acta. 2000 Sep 7;1493(1-2):269-72
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Gpr85:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr59852	Chr6:13839915-13839940 (-)	13 bp
Tssr59851	Chr6:13839894-13839907 (-)	40 bp
Tssr59850	Chr6:13839518-13839533 (-)	415 bp
Tssr59849	Chr6:13839485-13839509 (-)	444 bp
Tssr59848	Chr6:13839423-13839437 (-)	511 bp
Tssr59847	Chr6:13839317-13839339 (-)	613 bp
Tssr59846	Chr6:13839179-13839209 (-)	747 bp
Tssr59845	Chr6:13838651-13838688 (-)	1,271 bp
Tssr59844	Chr6:13838573-13838617 (-)	1,346 bp
Tssr59843	Chr6:13838431-13838441 (-)	1,505 bp
Tssr59842	Chr6:13838096-13838106 (-)	1,840 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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