Mmp19 MGI Mouse Gene Detail - MGI:1927899 - matrix metallopeptidase 19

Symbol

Mmp19
Name

matrix metallopeptidase 19

Feature Type

protein coding gene
IDs

MGI:1927899
NCBI Gene: 58223
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr10:128626779-128636693 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 77.16 cM
Mapping Data

3 experiments

SNPs within 2kb

273 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927899	protein coding gene	Chr10:128626779-128636696 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017882	protein coding gene	Chr10:132584299-132594170 (+)
A/J	MGP_AJ_G0017857	protein coding gene	Chr10:127244424-127255894 (+)
AKR/J	MGP_AKRJ_G0017820	protein coding gene	Chr10:130961306-130974291 (+)
BALB/cJ	MGP_BALBcJ_G0017821	protein coding gene	Chr10:127609128-127620000 (+)
C3H/HeJ	MGP_C3HHeJ_G0017644	protein coding gene	Chr10:131132139-131142524 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018276	protein coding gene	Chr10:137050240-137060094 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015954	protein coding gene	Chr10:121159587-121169456 (+)
CAST/EiJ	MGP_CASTEiJ_G0017205	protein coding gene	Chr10:131856810-131866645 (+)
CBA/J	MGP_CBAJ_G0017614	protein coding gene	Chr10:142643018-142652889 (+)
DBA/2J	MGP_DBA2J_G0017720	protein coding gene	Chr10:126302944-126312747 (+)
FVB/NJ	MGP_FVBNJ_G0017715	protein coding gene	Chr10:125226430-125236853 (+)
LP/J	MGP_LPJ_G0017794	protein coding gene	Chr10:133158684-133168494 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017743	protein coding gene	Chr10:145202364-145212235 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018316	protein coding gene	Chr10:131068718-131078596 (+)
PWK/PhJ	MGP_PWKPhJ_G0016990	protein coding gene	Chr10:126570349-126580753 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016779	protein coding gene	Chr10:130176621-130186647 (+)
WSB/EiJ	MGP_WSBEiJ_G0017264	protein coding gene	Chr10:131295406-131306754 (+)

Human Ortholog

MMP19, matrix metallopeptidase 19

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MMP19, matrix metallopeptidase 19
Synonyms

CODA, MMP18, RASI-1
Links

HGNC:7165

NCBI Gene ID: 4327

neXtProt AC: NX_Q99542

UniProt: Q99542
Chr Location

12q13.2; chr12:55835433-55842966 (-) GRCh38

MGI Vertebrate Homology

Mmp19 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MMP19
Protein SuperFamily

Peptidase_M10A_matrix
Gene Tree

Mmp19

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for one knock-out allele develop diet-induced obesity due to adipocyte hypertrophy and display decreased incidence of chemically-induced fibrosarcomas while another knock-out mutant shows a reduced inflammatory reaction to contact hypersensitivity and abnormal T cell differentiation.

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All GO Annotations

25
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

726
Tissues

12
cDNA Data

37
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mmp19

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All Sequences

49
RefSeq

4
UniProt

3
CCDS

CCDS24292.1, CCDS88116.1

Ensembl

ENSMUSG00000025355 (Evidence)
NCBI Gene

58223

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025355	Ensembl Gene Model \| MGI Sequence Detail	9915	C57BL/6J	± kb
transcript	ENSMUST00000026411	Ensembl \| MGI Sequence Detail	3402	Not Applicable
polypeptide	ENSMUSP00000026411	Ensembl \| MGI Sequence Detail	527	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010478 matrix metalloproteinase-19

(term hierarchy)
EC

3.4.24.-
InterPro Domains

IPR018486 Hemopexin, conserved site

IPR000585 Hemopexin-like domain

IPR036375 Hemopexin-like domain superfamily

IPR018487 Hemopexin-like repeats

IPR024079 Metallopeptidase, catalytic domain superfamily

IPR021190 Peptidase M10A

IPR033739 Peptidase M10A, catalytic domain

IPR001818 Peptidase M10, metallopeptidase

IPR006026 Peptidase, metallopeptidase

IPR002477 Peptidoglycan binding-like

IPR036365 PGBD-like superfamily
GlyGen

Q9JHI0 4 sites

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All nucleic 39

cDNA 38

Primer pair 1

Microarray probesets 3

Summaries

All 46

Developmental Gene Expression 6

Gene Ontology 8

Phenotypes 10
Earliest

J:65466 Mueller MS, et al., The murine ortholog of matrix metalloproteinase 19: its cloning, gene organization, and expression. Gene. 2000 Oct 3;256(1-2):101-11
Latest

J:324243 Lei Z, et al., EpCAM Is Essential to Maintaining the Immune Homeostasis of Intestines via Keeping the Expression of pIgR in the Intestinal Epithelium of Mice. Front Immunol. 2022;13:843378

TSS for Mmp19:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96448	Chr10:128626772-128626837 (+)	26 bp
Tssr96449	Chr10:128634811-128634848 (+)	8,051 bp
Tssr96450	Chr10:128635826-128635860 (+)	9,064 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24