Tspan3 MGI Mouse Gene Detail - MGI:1928098

Symbol

Tspan3
Name

tetraspanin 3
Synonyms

1700055K04Rik, tetraspanin, tetraspanin TM4-A homolog, TM4-A, Tm4sf8, Tspan-3

Feature Type

protein coding gene
IDs

MGI:1928098
NCBI Gene: 56434
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr9:56043168-56068354 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 30.13 cM, cytoband C
Mapping Data

2 experiments

SNPs within 2kb

707 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1928098	protein coding gene	Chr9:56039009-56072761 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034848	protein coding gene	Chr9:55276729-55302099 (-)
A/J	MGP_AJ_G0034829	protein coding gene	Chr9:53480707-53506083 (-)
AKR/J	MGP_AKRJ_G0034758	protein coding gene	Chr9:54722961-54751576 (-)
BALB/cJ	MGP_BALBcJ_G0034821	protein coding gene	Chr9:53268617-53294175 (-)
C3H/HeJ	MGP_C3HHeJ_G0034531	protein coding gene	Chr9:55182944-55212197 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035340	protein coding gene	Chr9:56832352-56857520 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032251	protein coding gene	Chr9:52832815-52857885 (-)
CAST/EiJ	MGP_CASTEiJ_G0033852	protein coding gene	Chr9:55220500-55247025 (-)
CBA/J	MGP_CBAJ_G0034502	protein coding gene	Chr9:58787856-58812995 (-)
DBA/2J	MGP_DBA2J_G0034661	protein coding gene	Chr9:53371396-53397139 (-)
FVB/NJ	MGP_FVBNJ_G0034603	protein coding gene	Chr9:52574798-52600180 (-)
LP/J	MGP_LPJ_G0034744	protein coding gene	Chr9:55564391-55589809 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034646	protein coding gene	Chr9:60301403-60326812 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035362	protein coding gene	Chr9:54725784-54751153 (-)
PWK/PhJ	MGP_PWKPhJ_G0033557	protein coding gene	Chr9:53375490-53401258 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033391	protein coding gene	Chr9:55008520-55035888 (-)
WSB/EiJ	MGP_WSBEiJ_G0033965	protein coding gene	Chr9:54659757-54687163 (-)

Human Ortholog

TSPAN3, tetraspanin 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TSPAN3, tetraspanin 3
Synonyms

TM4-A, TM4SF8, TSPAN-3
Links

HGNC:17752

NCBI Gene ID: 10099

neXtProt AC: NX_O60637

UniProt: O60637
Chr Location

15q24.3; chr15:77041404-77083984 (-) GRCh38

MGI Vertebrate Homology

Tspan3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TSPAN3
Protein SuperFamily

Tetraspanin
Gene Tree

Tspan3

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

1
Gene trapped

7
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available

Mice homozygous for a knock-out allele exhibit decreased hematopoietic stem cell number and decreased leukemia incidence.

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All GO Annotations

2
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

819
Tissues

24
cDNA Data

213
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tspan3

ZFIN tspan3a, tspan3b

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All Sequences

90
RefSeq

2
UniProt

11
CCDS

CCDS23207.1

Ensembl

ENSMUSG00000032324 (Evidence)
NCBI Gene

56434

			Length	Strain/Species	Flank
genomic	56434	NCBI Gene Model \| MGI Sequence Detail	25187	C57BL/6J	± kb
transcript	NM_019793	RefSeq \| MGI Sequence Detail	1747	C57BL/6
polypeptide	Q9QY33	UniProt \| EBI \| MGI Sequence Detail	253	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000016746 tetraspanin-3

(term hierarchy)
InterPro Domains

IPR000301 Tetraspanin, animals

IPR018503 Tetraspanin, conserved site

IPR008952 Tetraspanin, EC2 domain superfamily

IPR018499 Tetraspanin/Peripherin
GlyGen

Q9QY33 4 sites, 15 N-linked glycans (3 sites)

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All nucleic 214

cDNA 213

Other 1

Microarray probesets 3

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MGI:1920663

Summaries

All 38

Developmental Gene Expression 3

Gene Ontology 2

Phenotypes 9
Earliest

J:64920 Todd SC, et al., Sequences and expression of six new members of the tetraspanin/TM4SF family. Biochim Biophys Acta. 1998 Jul 30;1399(1):101-4
Latest

J:322847 Xing W, et al., Mice with Targeted Knockout of Tetraspanin 3 Exhibit Reduced Trabecular Bone Mass Caused by Decreased Osteoblast Functions. Cells. 2022 Mar 12;11(6)

TSS for Tspan3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr2883	Chr9:56068376-56068381 (-)	-25 bp
Tssr89697	Chr9:56068335-56068359 (-)	7 bp
Tssr89696	Chr9:56068282-56068329 (-)	48 bp
Tssr89695	Chr9:56068224-56068252 (-)	116 bp
Tssr89694	Chr9:56063146-56063148 (-)	5,207 bp
Tssr89693	Chr9:56052560-56052568 (-)	15,790 bp
Tssr89692	Chr9:56046668-56046669 (-)	21,685 bp
Tssr89691	Chr9:56043744-56043801 (-)	24,581 bp
Tssr89690	Chr9:56043655-56043674 (-)	24,689 bp
Tssr89689	Chr9:56043634-56043644 (-)	24,715 bp
Tssr89688	Chr9:56043529-56043570 (-)	24,804 bp
Tssr89687	Chr9:56043421-56043437 (-)	24,925 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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