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Nisch Gene Detail
Summary
  • Symbol
    Nisch
  • Name
    nischarin
  • Synonyms
    1200007D05Rik, 3202002H23Rik, edsn
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928323
    NCBI Gene: 64652
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:30892885-30928783 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 19.09 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    781 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928323
 protein coding gene Chr14:30892885-30938903 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021121
 protein coding gene Chr14:24344752-24391929 (-)
A/J MGP_AJ_G0021069
 protein coding gene Chr14:23424718-23470631 (-)
AKR/J MGP_AKRJ_G0021046
 protein coding gene Chr14:24548659-24594611 (-)
BALB/cJ MGP_BALBcJ_G0021073
 protein coding gene Chr14:23546781-23592897 (-)
C3H/HeJ MGP_C3HHeJ_G0020856
 protein coding gene Chr14:24415475-24464012 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021505
 protein coding gene Chr14:25314208-25360049 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019068
 protein coding gene Chr14:23488975-23535730 (-)
CAST/EiJ MGP_CASTEiJ_G0020381
 protein coding gene Chr14:24181474-24227998 (-)
CBA/J MGP_CBAJ_G0020823
 protein coding gene Chr14:26287376-26333362 (-)
DBA/2J MGP_DBA2J_G0020945
 protein coding gene Chr14:23454249-23500502 (-)
FVB/NJ MGP_FVBNJ_G0020929
 protein coding gene Chr14:23416604-23463207 (-)
LP/J MGP_LPJ_G0021014
 protein coding gene Chr14:24671728-24717767 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020955
 protein coding gene Chr14:25550414-25597169 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021538
 protein coding gene Chr14:24310007-24355919 (-)
PWK/PhJ MGP_PWKPhJ_G0020129
 protein coding gene Chr14:22910526-22957843 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019953
 protein coding gene Chr14:23905701-23951611 (-)
WSB/EiJ MGP_WSBEiJ_G0020436
 protein coding gene Chr14:24369284-24418541 (-)



Homology
more
  • Human Ortholog
    NISCH, nischarin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NISCH, nischarin
  • Synonyms
    hIRAS, I-1, IR1, IRAS
  • Links
    NCBI Gene ID: 11188
    neXtProt AC: NX_Q9Y2I1
    UniProt: Q9Y2I1

  • Chr Location
    3p21.1; chr3:52455118-52493068 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nisch mouse models; 1 with human NISCH associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 3 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for either a knock-out or hypomorphic allele exhibit hearing loss associated with increased susceptibility to otitis media.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    842
  • Tissues
    86
  • cDNA Data
    24
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 64652 NCBI Gene Model | MGI Sequence Detail 35899 C57BL/6J ±  kb
    transcript NM_022656 RefSeq | MGI Sequence Detail 5606 C57BL/6  
    polypeptide Q80TM9 UniProt | EBI | MGI Sequence Detail 1593 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 29
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1921365, MGI:1924216, MGI:2145818, MGI:3653500
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 8
      Phenotypes 21
    • Earliest
      J:66342 Alahari SK, et al., Nischarin, a novel protein that interacts with the integrin alpha5 subunit and inhibits cell migration. J Cell Biol. 2000 Dec 11;151(6):1141-54
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory