Slc2a5 MGI Mouse Gene Detail - MGI:1928369 - solute carrier family 2 (facilitated glucose transporter), member 5

Symbol

Slc2a5
Name

solute carrier family 2 (facilitated glucose transporter), member 5
Synonyms

GLUT5

Feature Type

protein coding gene
IDs

MGI:1928369
NCBI Gene: 56485
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr4:150203801-150228625 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 80.97 cM
Mapping Data

2 experiments

SNPs within 2kb

165 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1928369	protein coding gene	Chr4:150203740-150228626 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029150	protein coding gene	Chr4:154046272-154073836 (+)
A/J	MGP_AJ_G0029115	protein coding gene	Chr4:147598380-147625191 (+)
AKR/J	MGP_AKRJ_G0029063	protein coding gene	Chr4:151654146-151678612 (+)
BALB/cJ	MGP_BALBcJ_G0029131	protein coding gene	Chr4:148096821-148121708 (+)
C3H/HeJ	MGP_C3HHeJ_G0028852	protein coding gene	Chr4:152184882-152211090 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029580	protein coding gene	Chr4:159595384-159622890 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026826	protein coding gene	Chr4:140005838-140032469 (+)
CAST/EiJ	MGP_CASTEiJ_G0028265	protein coding gene	Chr4:149446914-149472859 (+)
CBA/J	MGP_CBAJ_G0028814	protein coding gene	Chr4:164294552-164325452 (+)
DBA/2J	MGP_DBA2J_G0028963	protein coding gene	Chr4:147692036-147717114 (+)
FVB/NJ	MGP_FVBNJ_G0028927	protein coding gene	Chr4:146819563-146847570 (+)
LP/J	MGP_LPJ_G0029053	protein coding gene	Chr4:153976074-154005811 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028954	protein coding gene	Chr4:167464047-167491322 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029612	protein coding gene	Chr4:152150464-152177804 (+)
PWK/PhJ	MGP_PWKPhJ_G0027985	protein coding gene	Chr4:143714907-143741134 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027819	protein coding gene	Chr4:146412425-146441281 (+)
WSB/EiJ	MGP_WSBEiJ_G0028345	protein coding gene	Chr4:152287959-152314900 (+)

Human Ortholog

SLC2A5, solute carrier family 2 member 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC2A5, solute carrier family 2 member 5
Synonyms

GLUT-5, GLUT5
Links

HGNC:11010

NCBI Gene ID: 6518

neXtProt AC: NX_P22732

UniProt: P22732
Chr Location

1p36.23; chr1:9035106-9094195 (-) GRCh38

MGI Vertebrate Homology

Slc2a5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC2A5
Gene Tree

Slc2a5

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

3
Gene trapped

7
Targeted

6
Genomic Mutations

1 involving Slc2a5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit normal cochlear morphology and physiology with no detectable alterations in outer hair cell morphology, electromotility or nonlinear capacitance.

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All GO Annotations

29
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

741
Tissues

35
cDNA Data

24
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc2a5

ZFIN slc2a5

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All Sequences

36
RefSeq

4
UniProt

1
CCDS

CCDS18968.1

Ensembl

ENSMUSG00000028976 (Evidence)
NCBI Gene

56485

			Length	Strain/Species	Flank
genomic	56485	NCBI Gene Model \| MGI Sequence Detail	24825	C57BL/6J	± kb
transcript	NM_019741	RefSeq \| MGI Sequence Detail	3096	C57BL/6
polypeptide	Q9WV38	UniProt \| EBI \| MGI Sequence Detail	501	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015068 solute carrier family 2, facilitated glucose transporter member 5

(term hierarchy)
InterPro Domains

IPR002442 Fructose transporter, type 5 (GLUT5)

IPR045263 Glucose transporter GLUT

IPR005828 Major facilitator, sugar transporter-like

IPR020846 Major facilitator superfamily domain

IPR036259 MFS transporter superfamily

IPR003663 Sugar/inositol transporter

IPR005829 Sugar transporter, conserved site
GlyGen

Q9WV38 1 site

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All nucleic 25

cDNA 24

Primer pair 1

Microarray probesets 3

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MGI:2140325

Summaries

All 59

Developmental Gene Expression 9

Gene Ontology 7

Phenotypes 22
Earliest

J:77251 Corpe CP, et al., Cloning and functional characterization of the mouse fructose transporter, GLUT5. Biochim Biophys Acta. 2002 Jun 7;1576(1-2):191-7
Latest

J:358420 Yan H, et al., Hexokinase 2 senses fructose in tumor-associated macrophages to promote colorectal cancer growth. Cell Metab. 2024 Nov 5;36(11):2449-2467.e6

TSS for Slc2a5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr40372	Chr4:150203732-150203788 (+)	-41 bp
Tssr40373	Chr4:150203795-150203806 (+)	0 bp
Tssr40374	Chr4:150205143-150205162 (+)	1,352 bp
Tssr1384	Chr4:150223785-150223800 (+)	19,992 bp
Tssr40375	Chr4:150223970-150223977 (+)	20,173 bp
Tssr40376	Chr4:150226740-150226745 (+)	22,942 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24