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Arpc3 Gene Detail
Summary
  • Symbol
    Arpc3
  • Name
    actin related protein 2/3 complex, subunit 3
  • Synonyms
    1110006A04Rik, Arp2/3 complex subunit p21-Arc, p21-Ar
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928375
    NCBI Gene: 56378
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:122529941-122544244 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 62.34 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    509 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928375
 protein coding gene Chr5:122529941-122552247 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030051
 protein coding gene Chr5:126023112-126045824 (+)
A/J MGP_AJ_G0030016
 protein coding gene Chr5:120800763-120823030 (+)
AKR/J MGP_AKRJ_G0029952
 protein coding gene Chr5:124691217-124716655 (+)
BALB/cJ MGP_BALBcJ_G0030027
 protein coding gene Chr5:122146853-122169102 (+)
C3H/HeJ MGP_C3HHeJ_G0029744
 protein coding gene Chr5:125307033-125333904 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030480
 protein coding gene Chr5:130866122-130892360 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027706
 protein coding gene Chr5:115412189-115435333 (+)
CAST/EiJ MGP_CASTEiJ_G0029153
 protein coding gene Chr5:124404756-124427830 (+)
CBA/J MGP_CBAJ_G0029714
 protein coding gene Chr5:136000123-136022477 (+)
DBA/2J MGP_DBA2J_G0029864
 protein coding gene Chr5:120858458-120880657 (+)
FVB/NJ MGP_FVBNJ_G0029820
 protein coding gene Chr5:119851054-119873414 (+)
LP/J MGP_LPJ_G0029953
 protein coding gene Chr5:126567192-126591760 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029851
 protein coding gene Chr5:139743276-139769004 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030521
 protein coding gene Chr5:124286507-124310646 (+)
PWK/PhJ MGP_PWKPhJ_G0028867
 protein coding gene Chr5:119629009-119653646 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028704
 protein coding gene Chr5:121982120-122005260 (+)
WSB/EiJ MGP_WSBEiJ_G0029228
 protein coding gene Chr5:124947651-124975520 (+)



Homology
more
  • Human Ortholog
    ARPC3, actin related protein 2/3 complex subunit 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARPC3, actin related protein 2/3 complex subunit 3
  • Synonyms
    ARC21, p21-Arc
  • Links
    NCBI Gene ID: 10094
    neXtProt AC: NX_O15145
    UniProt: O15145

  • Chr Location
    12q24.11; chr12:110434823-110450422 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 5 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    2 images
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transposon-induced allele develop only to the blastocyst stage and show defects in trophoblast outgrowth and in the dynamics of actin accumulation. Mice heterozygous for the same transposon-induced allele and a knock-out allele showimpaired trophoblast outgrowth activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    150
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56378 NCBI Gene Model | MGI Sequence Detail 14304 C57BL/6J ±  kb
    transcript NM_019824 RefSeq | MGI Sequence Detail 918 C57BL/6  
    polypeptide Q9JM76 UniProt | EBI | MGI Sequence Detail 178 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000004311 actin-related protein 2/3 complex subunit 3
      (term hierarchy)
    • PDB
      7AQK
    • InterPro Domains
      IPR007204 Actin-related protein 2/3 complex subunit 3
      IPR036753 Actin-related protein 2/3 complex subunit 3 superfamily
    • GlyGen
      Q9JM76 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 151
      cDNA 150
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1913400, MGI:2140738, MGI:2140961
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 2
      Gene Ontology 11
      Phenotypes 27
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:352813 Chioccioli M, et al., Stem cell migration drives lung repair in living mice. Dev Cell. 2024 Feb 14;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/17/2024
    MGI 6.24     		The Jackson Laboratory