Dpt MGI Mouse Gene Detail - MGI:1928392

Symbol

Dpt
Name

dermatopontin
Synonyms

1810032B19Rik, 5033416F05Rik, early quiescence protein-1, EQ-1

Feature Type

protein coding gene
IDs

MGI:1928392
NCBI Gene: 56429
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:164624232-164651843 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 72.12 cM, cytoband H2
Mapping Data

2 experiments

SNPs within 2kb

1206 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1928392	protein coding gene	Chr1:164624213-164651843 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016686	protein coding gene	Chr1:170240030-170267650 (+)
A/J	MGP_AJ_G0016667	protein coding gene	Chr1:163299407-163327029 (+)
AKR/J	MGP_AKRJ_G0016633	protein coding gene	Chr1:168247977-168275599 (+)
BALB/cJ	MGP_BALBcJ_G0016628	protein coding gene	Chr1:163802662-163830268 (+)
C3H/HeJ	MGP_C3HHeJ_G0016452	protein coding gene	Chr1:168451326-168479307 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017089	protein coding gene	Chr1:175956031-175983639 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014798	protein coding gene	Chr1:155240411-155277958 (+)
CAST/EiJ	MGP_CASTEiJ_G0016032	protein coding gene	Chr1:168101177-168129929 (+)
CBA/J	MGP_CBAJ_G0016427	protein coding gene	Chr1:182214092-182241714 (+)
DBA/2J	MGP_DBA2J_G0016533	protein coding gene	Chr1:162191884-162227422 (+)
FVB/NJ	MGP_FVBNJ_G0016531	protein coding gene	Chr1:160654433-160682211 (+)
LP/J	MGP_LPJ_G0016604	protein coding gene	Chr1:171338101-171365684 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016556	protein coding gene	Chr1:189750037-189781233 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017125	protein coding gene	Chr1:168099041-168126682 (+)
PWK/PhJ	MGP_PWKPhJ_G0015818	protein coding gene	Chr1:161383582-161414231 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015605	protein coding gene	Chr1:166960014-166989853 (+)
WSB/EiJ	MGP_WSBEiJ_G0016094	protein coding gene	Chr1:168248063-168276473 (+)

Human Ortholog

DPT, dermatopontin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DPT, dermatopontin
Synonyms

TRAMP
Links

HGNC:3011

NCBI Gene ID: 1805

neXtProt AC: NX_Q07507

UniProt: Q07507
Chr Location

1q24.2; chr1:168695468-168729206 (-) GRCh38

MGI Vertebrate Homology

Dpt stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DPT
Gene Tree

Dpt

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

2
Endonuclease-mediated

3
Targeted

3
Genomic Mutations

2 involving Dpt
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygotes for a targeted null mutation exhibit skin with increased elasticity, decreased thickness, and reduced collagen content, and possess more subcutaneous adipose tissue. Corneal thickness is reduced as well.

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All GO Annotations

7
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

836
Tissues

18
cDNA Data

75
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dpt

ZFIN dpt

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All Sequences

30
RefSeq

2
UniProt

1
CCDS

CCDS15437.1

Ensembl

ENSMUSG00000026574 (Evidence)
NCBI Gene

56429

			Length	Strain/Species	Flank
genomic	56429	NCBI Gene Model \| MGI Sequence Detail	27612	C57BL/6J	± kb
transcript	NM_019759	RefSeq \| MGI Sequence Detail	1713	C57BL/6
polypeptide	Q9QZZ6	UniProt \| EBI \| MGI Sequence Detail	201	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006670 dermatopontin

(term hierarchy)
InterPro Domains

IPR026645 Dermatopontin

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All nucleic 80

cDNA 75

Primer pair 1

Other 4

Microarray probesets 3

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MGI:1921422, MGI:1925481

Summaries

All 52

Developmental Gene Expression 14

Gene Ontology 7

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:340020 Ortiz-Munoz G, et al., In situ tumour arrays reveal early environmental control of cancer immunity. Nature. 2023 Jun;618(7966):827-833

TSS for Dpt:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9795	Chr1:164624186-164624197 (+)	-40 bp
Tssr9796	Chr1:164624200-164624218 (+)	-23 bp
Tssr9797	Chr1:164624265-164624290 (+)	46 bp
Tssr9798	Chr1:164624292-164624303 (+)	66 bp
Tssr9799	Chr1:164624304-164624315 (+)	78 bp
Tssr9800	Chr1:164624327-164624338 (+)	101 bp
Tssr9801	Chr1:164651407-164651413 (+)	27,178 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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