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Snx1 Gene Detail
Summary
  • Symbol
    Snx1
  • Name
    sorting nexin 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928395
    NCBI Gene: 56440
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:65995409-66032168 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 35.71 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    875 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928395
 protein coding gene Chr9:65995409-66033869 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034972
 protein coding gene Chr9:65890804-65931318 (-)
A/J MGP_AJ_G0034952
 protein coding gene Chr9:63636772-63675964 (-)
AKR/J MGP_AKRJ_G0034882
 protein coding gene Chr9:65152982-65194959 (-)
BALB/cJ MGP_BALBcJ_G0034945
 protein coding gene Chr9:63350719-63389337 (-)
C3H/HeJ MGP_C3HHeJ_G0034655
 protein coding gene Chr9:65682443-65722155 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035464
 protein coding gene Chr9:67678626-67717444 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032375
 protein coding gene Chr9:63294147-63333482 (-)
CAST/EiJ MGP_CASTEiJ_G0033976
 protein coding gene Chr9:65878961-65920751 (-)
CBA/J MGP_CBAJ_G0034626
 protein coding gene Chr9:70030091-70068889 (-)
DBA/2J MGP_DBA2J_G0034785
 protein coding gene Chr9:63411746-63451210 (-)
FVB/NJ MGP_FVBNJ_G0034727
 protein coding gene Chr9:62754217-62793821 (-)
LP/J MGP_LPJ_G0034868
 protein coding gene Chr9:66140435-66182836 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034769
 protein coding gene Chr9:71277071-71316891 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035486
 protein coding gene Chr9:65261441-65302900 (-)
PWK/PhJ MGP_PWKPhJ_G0033680
 protein coding gene Chr9:63610738-63649981 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033514
 protein coding gene Chr9:65548618-65589683 (-)
WSB/EiJ MGP_WSBEiJ_G0034089
 protein coding gene Chr9:65160675-65199629 (-)



Homology
more
  • Human Ortholog
    SNX1, sorting nexin 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SNX1, sorting nexin 1
  • Synonyms
    HsT17379, VPS5
  • Links
    NCBI Gene ID: 6642
    neXtProt AC: NX_Q13596
    UniProt: Q13596

  • Chr Location
    15q22.31; chr15:64094123-64146090 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    19 phenotypes from multigenic genotypes
    11 phenotype references
Homozygous mutant mice are viable and fertile and do not exhibit any apparent abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    7
  • cDNA Data
    157
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56440 NCBI Gene Model | MGI Sequence Detail 36760 C57BL/6J ±  kb
transcript NM_019727 RefSeq | MGI Sequence Detail 2079 C57BL/6  
polypeptide Q9WV80 UniProt | EBI | MGI Sequence Detail 522 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 159
    cDNA 157
    Primer pair 2

    Microarray probesets 6
References
more
  • Summaries
    All 52
    Developmental Gene Expression 7
    Gene Ontology 12
    Phenotypes 11
  • Earliest
    J:212820 Haft CR, et al., Identification of a family of sorting nexin molecules and characterization of their association with receptors. Mol Cell Biol. 1998 Dec;18(12):7278-87
  • Latest
    J:351573 Sasner M, et al., In vivo validation of late-onset Alzheimer's disease genetic risk factors. Alzheimers Dement. 2024 Jul;20(7):4970-4984
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory