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Il17b Gene Detail
Summary
  • Symbol
    Il17b
  • Name
    interleukin 17B
  • Synonyms
    1110006O16Rik, 1700006N07Rik, Zcyto7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928397
    NCBI Gene: 56069
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:61821006-61825609 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 34.67 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    219 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928397
 protein coding gene Chr18:61817958-61825609 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024482
 protein coding gene Chr18:61588604-61593146 (+)
A/J MGP_AJ_G0024449
 protein coding gene Chr18:58944789-58949413 (+)
AKR/J MGP_AKRJ_G0024419
 protein coding gene Chr18:60566656-60571263 (+)
BALB/cJ MGP_BALBcJ_G0024448
 protein coding gene Chr18:59070865-59075760 (+)
C3H/HeJ MGP_C3HHeJ_G0024216
 protein coding gene Chr18:60799729-60804256 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024895
 protein coding gene Chr18:63261540-63266139 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022326
 protein coding gene Chr18:58490219-58494629 (+)
CAST/EiJ MGP_CASTEiJ_G0023689
 protein coding gene Chr18:60683595-60688165 (+)
CBA/J MGP_CBAJ_G0024186
 protein coding gene Chr18:65310751-65318619 (+)
DBA/2J MGP_DBA2J_G0024316
 protein coding gene Chr18:58614552-58619132 (+)
FVB/NJ MGP_FVBNJ_G0024282
 protein coding gene Chr18:58026461-58031459 (+)
LP/J MGP_LPJ_G0024399
 protein coding gene Chr18:61446176-61450775 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024311
 protein coding gene Chr18:66879515-66884113 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024942
 protein coding gene Chr18:60780459-60785055 (+)
PWK/PhJ MGP_PWKPhJ_G0023432
 protein coding gene Chr18:58845710-58850400 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023238
 protein coding gene Chr18:61001159-61006916 (+)
WSB/EiJ MGP_WSBEiJ_G0023753
 protein coding gene Chr18:60628587-60634258 (+)



Homology
more
  • Human Ortholog
    IL17B, interleukin 17B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL17B, interleukin 17B
  • Synonyms
    IL-17B, IL-20, NIRF, ZCYTO7
  • Links
    NCBI Gene ID: 27190
    neXtProt AC: NX_Q9UHF5
    UniProt: Q9UHF5

  • Chr Location
    5q32; chr5:149371324-149404202 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit increased susceptibility to DDS-induced colitis and Citrobacter rodentium infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    766
  • Tissues
    42
  • cDNA Data
    38
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56069 NCBI Gene Model | MGI Sequence Detail 4604 C57BL/6J ±  kb
    transcript NM_019508 RefSeq | MGI Sequence Detail 692 Not Specified  
    polypeptide Q9QXT6 UniProt | EBI | MGI Sequence Detail 180 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 38
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1915790, MGI:1922686
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:62901 Shi Y, et al., A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity. J Biol Chem. 2000 Jun 23;275(25):19167-76
    • Latest
      J:346154 Huang Y, et al., Schwann cell promotes macrophage recruitment through IL-17B/IL-17RB pathway in injured peripheral nerves. Cell Rep. 2024 Feb 27;43(2):113753
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory