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Mlycd Gene Detail
Summary
  • Symbol
    Mlycd
  • Name
    malonyl-CoA decarboxylase
  • Synonyms
    Mcd
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928485
    NCBI Gene: 56690
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:120121617-120137841 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 67.64 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    698 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928485
 protein coding gene Chr8:120121591-120148577 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034180
 protein coding gene Chr8:122706311-122721928 (+)
A/J MGP_AJ_G0034160
 protein coding gene Chr8:117659213-117681786 (+)
AKR/J MGP_AKRJ_G0034087
 protein coding gene Chr8:121079184-121095352 (+)
BALB/cJ MGP_BALBcJ_G0034154
 protein coding gene Chr8:117868405-117884644 (+)
C3H/HeJ MGP_C3HHeJ_G0033865
 protein coding gene Chr8:121812806-121830191 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034674
 protein coding gene Chr8:126823996-126840301 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031616
 protein coding gene Chr8:110556159-110572570 (+)
CAST/EiJ MGP_CASTEiJ_G0033192
 protein coding gene Chr8:121742542-121762601 (+)
CBA/J MGP_CBAJ_G0033838
 protein coding gene Chr8:131437909-131454350 (+)
DBA/2J MGP_DBA2J_G0033994
 protein coding gene Chr8:116885730-116904655 (+)
FVB/NJ MGP_FVBNJ_G0033937
 protein coding gene Chr8:115907793-115924001 (+)
LP/J MGP_LPJ_G0034083
 protein coding gene Chr8:122858510-122876160 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033984
 protein coding gene Chr8:133889380-133908350 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034692
 protein coding gene Chr8:121229459-121246248 (+)
PWK/PhJ MGP_PWKPhJ_G0032894
 protein coding gene Chr8:116639515-116655280 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032734
 protein coding gene Chr8:119924932-119944943 (+)
WSB/EiJ MGP_WSBEiJ_G0033308
 protein coding gene Chr8:121948035-121965230 (+)



Homology
more
  • Human Ortholog
    MLYCD, malonyl-CoA decarboxylase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MLYCD, malonyl-CoA decarboxylase
  • Synonyms
    MCD
  • Links
    NCBI Gene ID: 23417
    neXtProt AC: NX_O95822
    UniProt: O95822

  • Chr Location
    16q23.3; chr16:83899115-83951445 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MLYCD associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit altered cardiac metabolism following ischemia and improved recovery.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    57
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    821
  • Tissues
    99
  • cDNA Data
    58
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000074064 Ensembl Gene Model | MGI Sequence Detail 16225 C57BL/6J ±  kb
transcript ENSMUST00000098367 Ensembl | MGI Sequence Detail 2128 Not Applicable  
polypeptide ENSMUSP00000095970 Ensembl | MGI Sequence Detail 492 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010461 malonyl-CoA decarboxylase, mitochondrial
    (term hierarchy)
  • EC
    4.1.1.9
  • InterPro Domains
    IPR038917 Malonyl-CoA decarboxylase
    IPR007956 Malonyl-CoA decarboxylase, C-terminal
    IPR042303 Malonyl-CoA decarboxylase, C-terminal catalytic domain superfamily
    IPR035372 Malonyl-CoA decarboxylase, N-terminal
    IPR038351 Malonyl-CoA decarboxylase, N-terminal domain superfamily
  • GlyGen
    Q99J39 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 60
    cDNA 58
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
less
MGI:2142507
References
more
  • Summaries
    All 56
    Developmental Gene Expression 6
    Gene Ontology 10
    Phenotypes 19
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:347631 Li C, et al., Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3 of Structural, Metabolic, and Contractile Related Genes. Adv Sci (Weinh). 2024 Mar;11(11):e2305992
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory